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Farnesyl Diphosphate Synthase (FDPS)

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FPS; Farnesyl Pyrophosphate Synthetase; Dimethylallyltranstransferase; Geranyltranstransferase

Farnesyl Diphosphate Synthase (FDPS)
CCC E162
HGNC 3631
MGI 104888
PubMed 17594374
RGD 68953
UniProt P14324
Farnesyl Diphosphate Synthase encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE162Hu01 Recombinant Farnesyl Diphosphate Synthase (FDPS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE162Hu01 Polyclonal Antibody to Farnesyl Diphosphate Synthase (FDPS) WB; IHC; ICC; IP.
MAE162Hu21 Monoclonal Antibody to Farnesyl Diphosphate Synthase (FDPS) WB; IHC; ICC; IP.
Assay Kits SEE162Hu ELISA Kit for Farnesyl Diphosphate Synthase (FDPS) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Farnesyl Diphosphate Synthase (FDPS) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Farnesyl Diphosphate Synthase (FDPS) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Farnesyl Diphosphate Synthase (FDPS) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Farnesyl Diphosphate Synthase (FDPS) CLIA Kit Customized Service Offer
n/a ELISA Kit for Farnesyl Diphosphate Synthase (FDPS) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE162Ra01 Recombinant Farnesyl Diphosphate Synthase (FDPS) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE162Ra21 Monoclonal Antibody to Farnesyl Diphosphate Synthase (FDPS) WB; IHC
PAE162Ra01 Polyclonal Antibody to Farnesyl Diphosphate Synthase (FDPS) WB; IHC; ICC; IP.
Assay Kits SEE162Ra ELISA Kit for Farnesyl Diphosphate Synthase (FDPS) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Isolation and sequence of the human farnesyl pyrophosphate synthetase cDNA. Coordinate regulation of the mRNAs for farnesyl pyrophosphate synthetase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, and 3-hydroxy-3-methylglutaryl coenzyme A synthase by phorbol ester."J. Biol. Chem. 265:4607-4614(1990) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells."Biochemistry 28:8129-8135(1989) [PubMed] [Europe PMC] [Abstract]
  7. "Oncoviral bovine leukemia virus G4 and human T-cell leukemia virus type 1 p13(II) accessory proteins interact with farnesyl pyrophosphate synthetase."J. Virol. 76:1400-1414(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts."Cell Host Microbe 2:96-105(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Farnesyl diphosphate synthase; regulation of product specificity."Acta Biochim. Pol. 52:45-55(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  14. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs."ChemMedChem 1:267-273(2006) [PubMed] [Europe PMC] [Abstract]
  17. "The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs."Proc. Natl. Acad. Sci. U.S.A. 103:7829-7834(2006) [PubMed] [Europe PMC] [Abstract]
  18. "Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation." J. Am. Chem. Soc. 131:5153-5162(2009) [PubMed] [Europe PMC] [Abstract]