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Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6)

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PACE4; SPC4; Paired Basic Amino Acid Cleaving System 4; Subtilisin-Like Proprotein Convertase 4; Subtilisin/Kexin-Like Protease PACE4

Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6)
CCC E186
HGNC 8569
MGI 102897
PubMed 21051773
RGD 3246
UniProt P29122
Wiki PCSK6
Proprotein convertase subtilisin/kexin type 6 is an enzyme that belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Each PACE4 isoform exhibits a unique restricted distribution. PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. PACE4A-II is at least expressed in placenta. PACE4B was only found in the embryonic kidney cell line from which it was isolated. PACE4C and PACE4D are expressed in placenta.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE186Hu01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) Positive Control; Immunogen; SDS-PAGE; WB.
RPE186Hu02 Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) Positive Control; Immunogen; SDS-PAGE; WB.
RPE186Hu03 Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE186Hu01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) Polyclonal Antibody Customized Service Offer
Assay Kits SEE186Ra ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 6 (PCSK6) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15."DNA Cell Biol. 10:757-769(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms."Biochem. Biophys. Res. Commun. 200:943-950(1994) [PubMed] [Europe PMC] [Abstract]
  3. ErratumBiochem. Biophys. Res. Commun. 204:1381-1382(1994) [PubMed] [Europe PMC] [Abstract]
  4. "A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus."J. Biochem. 121:941-948(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease."J. Biochem. 122:438-452(1997) [PubMed] [Europe PMC] [Abstract]
  6. "Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform."FEBS Lett. 396:31-36(1996) [PubMed] [Europe PMC] [Abstract]
  7. "Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain."Biochem. J. 339:639-647(1999) [PubMed] [Europe PMC] [Abstract]
  8. "Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4)."FEBS Lett. 434:155-159(1998) [PubMed] [Europe PMC] [Abstract]