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Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1)

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PC1, PC3, SPC3; NEC1; Prohormone Convertase 3; Prohormone Convertase 1; Neuroendocrine Convertase 1; Proprotein Convertase 1

Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1)
CCC E190
HGNC 8743
MGI 97511
PubMed 21805247
RGD 3272
UniProt P29120
Wiki PCSK1
Proprotein Convertase Subtilisin/Kexin Type 1 is aprotein belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. The use of alternate polyadenylation sites has been found for this gene. Multiple alternatively spliced transcript variants have been described for this gene but their full length nature is not known.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE190Hu01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE190Hu01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) WB; IHC; ICC; IP.
MAE190Hu21 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) WB; IHC; ICC; IP.
Assay Kits SEE190Hu ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE190Mu01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE190Mu01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE190Ra01 Recombinant Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE190Ra21 Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) WB; IHC; ICC; IP.
PAE190Ra01 Polyclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) WB; IHC; ICC; IP.
Assay Kits SEE190Ra ELISA Kit for Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  10. ErratumNat. Genet. 23:373-373(1999)
  11. "Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency." J. Clin. Invest. 112:1550-1560(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3."J. Clin. Endocrinol. Metab. 92:3369-3373(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Common nonsynonymous variants in PCSK1 confer risk of obesity." Nat. Genet. 40:943-945(2008) [PubMed] [Europe PMC] [Abstract]