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Gap Junction Protein Beta 7 (GJb7)

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CX25; Connexin 25

Gap Junction Protein Beta 7 (GJb7)
CCC E197
HGNC 16690
PubMed 12064583
UniProt Q6PEY0
Wiki GJB7
Connexins, such as GJB7, are involved in the formation of gap junctions, intercellular conduits that directly connect the cytoplasms of contacting cells. Each gap junction channel is formed by docking of 2 hemichannels, each of which contains 6 connexin subunits.
By database analysis and PCR of human genomic DNA, Sohl et al. (2003) cloned GJB7, which they called CX25. Northern blot analysis detected weak expression of a 2.7-kb CX25 transcript in placenta only. Sohl et al. (2003) stated that there is no ortholog of CX25 in mouse.Hartz (2008) mapped the GJB7 gene to chromosome 6q15 based on an alignment of the GJB7 sequence with the genomic sequence (build 36.1).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gap Junction Protein Beta 7 (GJb7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gap Junction Protein Beta 7 (GJb7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gap Junction Protein Beta 7 (GJb7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gap Junction Protein Beta 7 (GJb7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gap Junction Protein Beta 7 (GJb7) ELISA Kit Customized Service Offer
  1. "Structural and functional diversity of connexin genes in the mouse and human genome."Biol. Chem. 383:725-737(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning and functional expression of a novel human connexin-25 gene."Cell Commun. Adhes. 8:167-171(2001) [PubMed] [Europe PMC] [Abstract]
  6. "Expression profiles of the novel human connexin genes hCx30.2, hCx40.1, and hCx62 differ from their putative mouse orthologues."Cell Commun. Adhes. 10:27-36(2003) [PubMed] [Europe PMC] [Abstract]