≡

Farnesylated Protein Converting Enzyme 1 (FACE1)

[Edit]

ZMPSTE24; STE24; Ste24p; HGPS; PRO1; Zinc Metallopeptidase STE24; CAAX prenyl protease 1; Hutchinson-Gilford Progeria Syndrome; ; Prenyl protein-specific endoprotease 1

Farnesylated Protein Converting Enzyme 1 (FACE1)
CCC E207
HGNC 12877
MGI 1890508
PubMed 19453269
RGD 1305570
UniProt O75844
Wiki ZMPSTE24
ZMPSTE24 isa member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy.
The protein is a protein essential for the proteolytic processing of yeast farnesylated/prenylated proteins. ZMPSTE24 encodes a deduced 475-amino acid protein that shares 36% sequence identity with S. cerevisiae Ste24. ZMPSTE24 contains a characteristic HEXXH zinc metalloprotease motif, several transmembrane regions, and regions I, II, and III that are conserved among a subfamily of zinc metalloproteases.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Farnesylated Protein Converting Enzyme 1 (FACE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Farnesylated Protein Converting Enzyme 1 (FACE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Farnesylated Protein Converting Enzyme 1 (FACE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Farnesylated Protein Converting Enzyme 1 (FACE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Farnesylated Protein Converting Enzyme 1 (FACE1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Farnesylated Protein Converting Enzyme 1 (FACE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Farnesylated Protein Converting Enzyme 1 (FACE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Farnesylated Protein Converting Enzyme 1 (FACE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Farnesylated Protein Converting Enzyme 1 (FACE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Farnesylated Protein Converting Enzyme 1 (FACE1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Farnesylated Protein Converting Enzyme 1 (FACE1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Farnesylated Protein Converting Enzyme 1 (FACE1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Farnesylated Protein Converting Enzyme 1 (FACE1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Farnesylated Protein Converting Enzyme 1 (FACE1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Farnesylated Protein Converting Enzyme 1 (FACE1) ELISA Kit Customized Service Offer
  1. "Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p."Biochim. Biophys. Acta 1426:468-474(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing."J. Cell Biol. 142:635-649(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins."Genomics 58:270-280(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "The structural basis of ZMPSTE24-dependent laminopathies."Science 339:1604-1607(2013) [PubMed] [Europe PMC] [Abstract]
  10. "Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia."Hum. Mol. Genet. 12:1995-2001(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy."Hum. Mol. Genet. 13:2493-2503(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Focal segmental glomerulosclerosis in patients with mandibuloacral dysplasia owing to ZMPSTE24 deficiency."J. Invest. Med. 54:208-213(2006) [PubMed] [Europe PMC] [Abstract]
  13. "Severe mandibuloacral dysplasia caused by novel compound heterozygous ZMPSTE24 mutations in two Japanese siblings."Clin. Genet. 73:535-544(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Early onset mandibuloacral dysplasia due to compound heterozygous mutations in ZMPSTE24."Am. J. Med. Genet. A 152:2703-2710(2010) [PubMed] [Europe PMC] [Abstract]