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Aspartate Carbamoyltransferase (ATCase)

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CAD; Aspartate Transcarbamoylase; Glutamine-dependent carbamoyl-phosphate synthase; Carbamoyl-Phosphate Synthetase 2,Aspartate Transcarbamylase,And Dihydroorotase

Aspartate Carbamoyltransferase (ATCase)
CCC E218
HGNC 1424
MGI 1916969
PubMed 2543974
RGD 1588606
UniProt P27708
Wiki CAD
Aspartate carbamoyltransferase catalyzes the first step in the pyrimidine biosynthetic pathway.The composition of the subunits is C6R6, forming 2 trimers of catalytic subunitsand 3 dimers of regulatory subunits. The particular arrangement of catalytic and regulatory subunits in this enzyme affords the complex with strongly allosteric behaviour with respect to its substrates. The enzyme is an archetypal example of allosteric modulation of fine control of metabolic enzyme reactions.
ATCase does not follow Michaelis-Menten kinetics, but lies between the high-activity, high-affinity "relaxed" or R and the low-activity, low-affinity "tense" or T states. The binding of substrate to the catalytic subunits result in an equilibrium shift towards the R state, whereas binding of CTP to the regulatory subunits results in an equilibrium shift towards the T state.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aspartate Carbamoyltransferase (ATCase) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aspartate Carbamoyltransferase (ATCase) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aspartate Carbamoyltransferase (ATCase) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aspartate Carbamoyltransferase (ATCase) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aspartate Carbamoyltransferase (ATCase) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aspartate Carbamoyltransferase (ATCase) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aspartate Carbamoyltransferase (ATCase) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aspartate Carbamoyltransferase (ATCase) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aspartate Carbamoyltransferase (ATCase) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aspartate Carbamoyltransferase (ATCase) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Aspartate Carbamoyltransferase (ATCase) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Aspartate Carbamoyltransferase (ATCase) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Aspartate Carbamoyltransferase (ATCase) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Aspartate Carbamoyltransferase (ATCase) CLIA Kit Customized Service Offer
n/a ELISA Kit for Aspartate Carbamoyltransferase (ATCase) ELISA Kit Customized Service Offer
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  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. , Submitted (FEB-2008) to UniProtKB
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  8. "Transcriptional repression of human cad gene by hypoxia inducible factor-1alpha."Nucleic Acids Res. 33:5190-5198(2005) [PubMed] [Europe PMC] [Abstract]
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  11. "Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD, by MAP kinase."Front. Biosci. 12:3892-3898(2007) [PubMed] [Europe PMC] [Abstract]
  12. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  13. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  21. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis."Science 339:1320-1323(2013) [PubMed] [Europe PMC] [Abstract]
  23. "Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1."Science 339:1323-1328(2013) [PubMed] [Europe PMC] [Abstract]
  24. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  25. "Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD."Structure 22:185-198(2014) [PubMed] [Europe PMC] [Abstract]
  26. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]