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Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1)

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DOD; Protein(Peptidyl-Prolyl Cis/Trans Isomerase)NIMA-Interacting 1; Peptidyl-prolyl cis-trans isomerase Pin1; Rotamase Pin1

Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1)
CCC E219
HGNC 8988
MGI 1346036
PubMed 21454638
RGD 1310299
UniProt Q13526
Wiki Pin1
Peptidyl-prolyl cis/trans isomerases (PPIases; EC 5.2.1.8), such as PIN1, catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. PIN1 is the only PPIase that specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. PIN1-catalyzed conformational regulation has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, germ cell development, neuronal differentiation, and survival. Both Drosophila and human DOD contain a WW domain for protein-protein interactions and a peptidylprolyl cis-trans isomerase (PPIase) domain, and they are related to the Ess1 cell division gene of Saccharomyces cerevisiae.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE219Hu01 Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE219Hu01 Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) WB; IHC; ICC; IP.
PAE219Hu02 Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) WB; IHC; ICC; IP.
MAE219Hu22 Monoclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) WB; IHC; ICC; IP.
LAE219Hu71 Biotin-Linked Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) WB; IHC; ICC.
LAE219Hu81 FITC-Linked Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) WB; IHC; ICC; IF.
Assay Kits SEE219Hu ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE219Mu01 Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE219Mu01 Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) WB; IHC; ICC; IP.
LAE219Mu71 Biotin-Linked Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) WB; IHC; ICC.
LAE219Mu81 FITC-Linked Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidyl Prolyl Cis/Trans Isomerase NIMA Interacting Protein 1 (PIN1) ELISA Kit Customized Service Offer
  1. "A human peptidyl-prolyl isomerase essential for regulation of mitosis."Nature 380:544-547(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1."J. Biol. Chem. 276:37520-37528(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Regulation of Raf-1 by direct feedback phosphorylation."Mol. Cell 17:215-224(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients."Biochem. Biophys. Res. Commun. 341:1059-1065(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1."J. Biol. Chem. 281:18201-18207(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells."Nat. Immunol. 8:1132-1139(2007) [PubMed] [Europe PMC] [Abstract]
  9. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons."PLoS ONE 3:E2686-E2686(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Protein kinase-X interacts with Pin-1 and Polycystin-1 during mouse kidney development."Kidney Int. 76:54-62(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover."J. Biol. Chem. 286:44403-44411(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function."Mol. Cell 42:147-159(2011) [PubMed] [Europe PMC] [Abstract]
  16. "Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase."Mol. Cell 46:771-783(2012) [PubMed] [Europe PMC] [Abstract]
  17. "Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent."Cell 89:875-886(1997) [PubMed] [Europe PMC] [Abstract]