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Peptidylprolyl Isomerase H (PPIH)

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PPI-H; CYPH; CYP-20; SnuCyp-20; USA-CYP; Cyclophilin H; Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H; Rotamase H; Peptidyl-Prolyl Cis-Trans Isomerase H

Peptidylprolyl Isomerase H (PPIH)
CCC E220
HGNC 14651
MGI 106499
PubMed 9722123
RGD 1564921
UniProt O43447
Wiki PPIH
Peptidyl-prolyl cis-trans isomerase H is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP.
This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.PPIH encodes a deduced 177-amino acid protein that shares 68% and 55% sequence identity with C. elegans CyP-11 and human cyclophilin A (PPIA), respectively.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidylprolyl Isomerase H (PPIH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidylprolyl Isomerase H (PPIH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidylprolyl Isomerase H (PPIH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidylprolyl Isomerase H (PPIH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidylprolyl Isomerase H (PPIH) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidylprolyl Isomerase H (PPIH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidylprolyl Isomerase H (PPIH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidylprolyl Isomerase H (PPIH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidylprolyl Isomerase H (PPIH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidylprolyl Isomerase H (PPIH) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peptidylprolyl Isomerase H (PPIH) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peptidylprolyl Isomerase H (PPIH) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peptidylprolyl Isomerase H (PPIH) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peptidylprolyl Isomerase H (PPIH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peptidylprolyl Isomerase H (PPIH) ELISA Kit Customized Service Offer
  1. "A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs."RNA 3:1374-1387(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins."RNA 4:127-141(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A cyclophilin functions in pre-mRNA splicing."EMBO J. 21:470-480(2002) [PubMed] [Europe PMC] [Abstract]
  7. "The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP."RNA 12:1418-1430(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin."J. Biol. Chem. 275:7439-7442(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide."J. Mol. Biol. 331:45-56(2003) [PubMed] [Europe PMC] [Abstract]