Hyaluronoglucosaminidase 2 (HYAL2)
[Edit]LUCA2; LuCa-2; Lysosomal Hyaluronidase; PH-20 Homolog; Hyaluronidase 2; Lung carcinoma protein 2
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Hyaluronidase-2 is a protein which is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. Varying functions have been described for this protein. It has been described as a lysosomal hyaluronidase which is active at a pH below 4 and specifically hydrolyzes high molecular weight hyaluronan. It has also been described as a GPI-anchored cell surface protein which does not display hyaluronidase activity but does serve as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Hyaluronoglucosaminidase 2 (HYAL2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Hyaluronoglucosaminidase 2 (HYAL2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Hyaluronoglucosaminidase 2 (HYAL2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Hyaluronoglucosaminidase 2 (HYAL2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hyaluronoglucosaminidase 2 (HYAL2) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPE237Mu01 | Recombinant Hyaluronoglucosaminidase 2 (HYAL2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAE237Mu01 | Polyclonal Antibody to Hyaluronoglucosaminidase 2 (HYAL2) | WB; IHC; ICC; IP. |
| LAE237Mu71 | Biotin-Linked Polyclonal Antibody to Hyaluronoglucosaminidase 2 (HYAL2) | WB; IHC; ICC. | |
| LAE237Mu81 | FITC-Linked Polyclonal Antibody to Hyaluronoglucosaminidase 2 (HYAL2) | WB; IHC; ICC; IF. | |
| Assay Kits | n/a | CLIA Kit for Hyaluronoglucosaminidase 2 (HYAL2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hyaluronoglucosaminidase 2 (HYAL2) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Hyaluronoglucosaminidase 2 (HYAL2) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Hyaluronoglucosaminidase 2 (HYAL2) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Hyaluronoglucosaminidase 2 (HYAL2) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Hyaluronoglucosaminidase 2 (HYAL2) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hyaluronoglucosaminidase 2 (HYAL2) | ELISA Kit Customized Service Offer |
- "HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity."J. Biol. Chem. 273:22466-22470(1998) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "The DNA sequence, annotation and analysis of human chromosome 3." Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Hyal2 -- less active, but more versatile?"Matrix Biol. 20:509-514(2001) [PubMed] [Europe PMC] [Abstract]
- "Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation."Proc. Natl. Acad. Sci. U.S.A. 98:4443-4448(2001) [PubMed] [Europe PMC] [Abstract]
- "Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus."Proc. Natl. Acad. Sci. U.S.A. 100:4580-4585(2003) [PubMed] [Europe PMC] [Abstract]