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Cysteine Dioxygenase I (CDO1)

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Cysteine Dioxygenase I (CDO1)
CCC E248
HGNC 1795
MGI 105925
RGD 69262
UniProt Q16878
Cysteine dioxygenase (CDO) is a mammalian non-heme iron enzyme that catalyzes the conversion of L-cysteine to cysteine sulfinic acid (cysteine sulfinate) by incorporation of dioxygen.The first step in the oxidation of cysteine to inorganic sulfate is its conversion to cysteine sulphinate by cysteine dioxygenase (CDO).
In rat, at least 2 enzymes catalyze this reaction, one cytosolic (CDO-I) and the other membrane-bound. Rat liver CDO contains 1 atom of iron per molecule of protein, and the enzyme is activated by anaerobic incubation with either L-cysteine or its analogs. The predicted 200-amino acid human and rat proteins are 94% identical. Northern blot analysis revealed that CDO-I is expressed as an approximately 1.5-kb mRNA in liver.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE248Hu01 Recombinant Cysteine Dioxygenase I (CDO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE248Hu01 Polyclonal Antibody to Cysteine Dioxygenase I (CDO1) WB
Assay Kits n/a CLIA Kit for Cysteine Dioxygenase I (CDO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cysteine Dioxygenase I (CDO1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE248Mu01 Recombinant Cysteine Dioxygenase I (CDO1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE248Mu01 Polyclonal Antibody to Cysteine Dioxygenase I (CDO1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cysteine Dioxygenase I (CDO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cysteine Dioxygenase I (CDO1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cysteine Dioxygenase I (CDO1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cysteine Dioxygenase I (CDO1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cysteine Dioxygenase I (CDO1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cysteine Dioxygenase I (CDO1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cysteine Dioxygenase I (CDO1) ELISA Kit Customized Service Offer
  1. "Human cysteine dioxygenase type I: primary structure derived from base sequencing of cDNA."Biochim. Biophys. Acta 1209:107-110(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Human cysteine dioxygenase gene: structural organization, tissue-specific expression and downregulation by phorbol 12-myristate 13-acetate."Biosci. Biotechnol. Biochem. 63:1017-1024(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Human cysteine dioxygenase type I (CDO-I; EC 1.13.11.20): 5' flanking region and intron-exon structure of the gene."Mol. Pathol. 50:269-271(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  7. "An insight into the mechanism of human cysteine dioxygenase. Key roles of the thioether-bonded tyrosine-cysteine cofactor."J. Biol. Chem. 282:3391-3402(2007) [PubMed] [Europe PMC] [Abstract]
  8. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]