Cytohesin 3 (CYTH3)
[Edit]PSCD3; ARNO3; GRP1; Pleckstrin Homology,Sec7 And Coiled-Coil Domains 3; ARF nucleotide-binding site opener 3; General receptor of phosphoinositides 1
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Cytohesin-3 is a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cytohesin 3 (CYTH3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cytohesin 3 (CYTH3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cytohesin 3 (CYTH3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cytohesin 3 (CYTH3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cytohesin 3 (CYTH3) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cytohesin 3 (CYTH3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cytohesin 3 (CYTH3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cytohesin 3 (CYTH3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cytohesin 3 (CYTH3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cytohesin 3 (CYTH3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Cytohesin 3 (CYTH3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Cytohesin 3 (CYTH3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Cytohesin 3 (CYTH3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Cytohesin 3 (CYTH3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Cytohesin 3 (CYTH3) | ELISA Kit Customized Service Offer |
- "Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain."Biochem. J. 335:139-146(1998) [PubMed] [Europe PMC] [Abstract]
- "ARNO3, a Sec7-domain guanine nucleotide exchange factor for ADP ribosylation factor 1, is involved in the control of Golgi structure and function."Proc. Natl. Acad. Sci. U.S.A. 95:9926-9931(1998) [PubMed] [Europe PMC] [Abstract]
- "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Similarities in function and gene structure of cytohesin-4 and cytohesin-1, guanine nucleotide-exchange proteins for ADP-ribosylation factors."J. Biol. Chem. 275:3221-3230(2000) [PubMed] [Europe PMC] [Abstract]
- "The Arl4 family of small G proteins can recruit the cytohesin Arf6 exchange factors to the plasma membrane."Curr. Biol. 17:711-716(2007) [PubMed] [Europe PMC] [Abstract]
- "Structural basis for membrane recruitment and allosteric activation of cytohesin family Arf GTPase exchange factors."Proc. Natl. Acad. Sci. U.S.A. 110:14213-14218(2013) [PubMed] [Europe PMC] [Abstract]