≡

Ran GTPase Activating Protein 1 (RANGAP1)

[Edit]

Fug1; SD; Segregation Distorter Homolog

Ran GTPase Activating Protein 1 (RANGAP1)
CCC E296
HGNC 9854
MGI 103071
PubMed 15931224
RGD 1310380
UniProt P46060
Wiki RANGAP1
RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.Highly expressed in brain, thymus and testis.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ran GTPase Activating Protein 1 (RANGAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ran GTPase Activating Protein 1 (RANGAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ran GTPase Activating Protein 1 (RANGAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ran GTPase Activating Protein 1 (RANGAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ran GTPase Activating Protein 1 (RANGAP1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ran GTPase Activating Protein 1 (RANGAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ran GTPase Activating Protein 1 (RANGAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ran GTPase Activating Protein 1 (RANGAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ran GTPase Activating Protein 1 (RANGAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ran GTPase Activating Protein 1 (RANGAP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ran GTPase Activating Protein 1 (RANGAP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ran GTPase Activating Protein 1 (RANGAP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ran GTPase Activating Protein 1 (RANGAP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ran GTPase Activating Protein 1 (RANGAP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ran GTPase Activating Protein 1 (RANGAP1) ELISA Kit Customized Service Offer
  1. "Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport."Proc. Natl. Acad. Sci. U.S.A. 92:1749-1753(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  4. "A genome annotation-driven approach to cloning the human ORFeome."Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 22." Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Ubiquitous expression and testis-specific alternative polyadenylation of mRNA for the human Ran GTPase activator RanGAP1."Gene 180:7-11(1996) [PubMed] [Europe PMC] [Abstract]
  8. "SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles."J. Cell Biol. 156:595-602(2002) [PubMed] [Europe PMC] [Abstract]
  9. "RanGAP1*SUMO1 is phosphorylated at the onset of mitosis and remains associated with RanBP2 upon NPC disassembly."J. Cell Biol. 164:965-971(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Nuclear tumor necrosis factor receptor-associated factor 6 in lymphoid cells negatively regulates c-Myb-mediated transactivation through small ubiquitin-related modifier-1 modification."J. Biol. Chem. 283:5081-5089(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  16. "In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification."J. Biol. Chem. 285:19324-19329(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex."Nature 435:687-692(2005) [PubMed] [Europe PMC] [Abstract]
  21. "SUMO protease SENP1 induces isomerization of the scissile peptide bond."Nat. Struct. Mol. Biol. 13:1069-1077(2006) [PubMed] [Europe PMC] [Abstract]