≡

RAP1 GTPase Activating Protein (RAP1GAP)

[Edit]

RAP1GA1; rap1GAPII

RAP1 GTPase Activating Protein (RAP1GAP)
CCC E297
HGNC 9858
MGI 109338
PubMed 20124489
RGD 1309908
UniProt P47736
Wiki RAP1GAP
Specific GTPase-activating proteins that play regulatory roles in this enzymatic process have been identified for RAS homologous protein (ARHG) and RAP1A. The best defined of these is RAS-GTPase activating protein (RASA), overexpression of which can suppress the transforming activity of RAS.
The p21 protein RAP1 is of particular interest since it has been shown to be an antagonist of RAS and is capable of suppressing cellular transformation. It has been suggested that RAP1 binds competitively to RASA, thus interfering with its RAS effector functions.It was shown to be highly expressed in undifferentiated tumor cells, suggesting that it may have a role in differentiation and growth of malignant cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAP1 GTPase Activating Protein (RAP1GAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAP1 GTPase Activating Protein (RAP1GAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAP1 GTPase Activating Protein (RAP1GAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAP1 GTPase Activating Protein (RAP1GAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAP1 GTPase Activating Protein (RAP1GAP) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAP1 GTPase Activating Protein (RAP1GAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAP1 GTPase Activating Protein (RAP1GAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAP1 GTPase Activating Protein (RAP1GAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAP1 GTPase Activating Protein (RAP1GAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAP1 GTPase Activating Protein (RAP1GAP) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant RAP1 GTPase Activating Protein (RAP1GAP) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to RAP1 GTPase Activating Protein (RAP1GAP) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to RAP1 GTPase Activating Protein (RAP1GAP) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for RAP1 GTPase Activating Protein (RAP1GAP) CLIA Kit Customized Service Offer
n/a ELISA Kit for RAP1 GTPase Activating Protein (RAP1GAP) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1."Cell 65:1033-1042(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain."DNA Res. 4:345-349(1997) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)."Nature 400:891-894(1999) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Human SPA-1 product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2."J. Biol. Chem. 272:28081-28088(1997) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "The GTPase-activating protein Rap1GAP uses a catalytic asparagine."Nature 429:197-201(2004) [PubMed] [Europe PMC] [Abstract]
  13. "The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues."EMBO J. 27:1145-1153(2008) [PubMed] [Europe PMC] [Abstract]
  14. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]