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Ras Homolog Gene Family, Member C (RHOC)

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ARH9; ARHC; H9; RHOH9; Rho cDNA clone 9

Ras Homolog Gene Family, Member C (RHOC)
CCC E321
HGNC 669
MGI 106028
PubMed 24096540
RGD 1304965
UniProt P08134
Wiki RHOC
RhoC (Ras homolog gene family, member C) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.It cycles between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility.
It is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member C (RHOC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member C (RHOC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member C (RHOC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Gene Family, Member C (RHOC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Gene Family, Member C (RHOC) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member C (RHOC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member C (RHOC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member C (RHOC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Gene Family, Member C (RHOC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Gene Family, Member C (RHOC) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ras Homolog Gene Family, Member C (RHOC) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ras Homolog Gene Family, Member C (RHOC) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ras Homolog Gene Family, Member C (RHOC) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ras Homolog Gene Family, Member C (RHOC) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ras Homolog Gene Family, Member C (RHOC) ELISA Kit Customized Service Offer
  1. "Coding sequence of human rho cDNAs clone 6 and clone 9."Nucleic Acids Res. 16:2717-2717(1988) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton."Mol. Cell. Biol. 16:5313-5327(1996) [PubMed] [Europe PMC] [Abstract]
  6. "AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation."J. Biol. Chem. 276:44247-44257(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Dissecting the role of Rho-mediated signaling in contractile ring formation."Mol. Biol. Cell 17:43-55(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1."Nat. Cell Biol. 12:477-483(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells."Mol. Cell. Biol. 31:81-91(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Structural and mechanistic insights into the interaction between Rho and mammalian Dia."Nature 435:513-518(2005) [PubMed] [Europe PMC] [Abstract]