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GDP Dissociation Inhibitor 2 (GDI2)

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RABGDIB; GDIB; Rab GDP Dissociation Inhibitor Beta; Guanosine diphosphate dissociation inhibitor 2

GDP Dissociation Inhibitor 2 (GDI2)
CCC E332
HGNC 4227
MGI 99845
PubMed 20948920
RGD 61802
UniProt P50395
Wiki GDI2
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements.
Bachner et al. (1995) studied expression patterns of the 2 human genes. They showed that the 2.5-kb mRNA for RABGDIB is ubiquitously expressed, in contrast to RABGDIA, which is expressed primarily in neural and sensory tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GDP Dissociation Inhibitor 2 (GDI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GDP Dissociation Inhibitor 2 (GDI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GDP Dissociation Inhibitor 2 (GDI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GDP Dissociation Inhibitor 2 (GDI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GDP Dissociation Inhibitor 2 (GDI2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GDP Dissociation Inhibitor 2 (GDI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GDP Dissociation Inhibitor 2 (GDI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GDP Dissociation Inhibitor 2 (GDI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GDP Dissociation Inhibitor 2 (GDI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GDP Dissociation Inhibitor 2 (GDI2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant GDP Dissociation Inhibitor 2 (GDI2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to GDP Dissociation Inhibitor 2 (GDI2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to GDP Dissociation Inhibitor 2 (GDI2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for GDP Dissociation Inhibitor 2 (GDI2) CLIA Kit Customized Service Offer
n/a ELISA Kit for GDP Dissociation Inhibitor 2 (GDI2) ELISA Kit Customized Service Offer
  1. "The human rab GDI beta gene with long retroposon-rich introns maps to 10p15 and its pseudogene to 7p11-p13."Mamm. Genome 9:78-80(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells."J. Cell. Biochem. 79:628-647(2000) [PubMed] [Europe PMC] [Abstract]
  6. "Expression patterns of two human genes coding for different rab GDP-dissociation inhibitors (GDIs), extremely conserved proteins involved in cellular transport."Hum. Mol. Genet. 4:701-708(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function."Mol. Cell. Biol. 22:1158-1171(2002) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]