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Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1)

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SLC4A4; HNBC1; KNBC; NBC2; hhNMC; pNBC; Na(+)/HCO3(-) cotransporter; Solute Carrier Family 4 Member 4,Sodium Bicarbonate Cotransporter

Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1)
CCC E364
HGNC 11030
MGI 1927555
PubMed 10876088
RGD 68936
UniProt Q9Y6R1
Wiki SLC4A4
SLC4A4 encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Electrogenic Sodium Bicarbonate Cotransporter 1 (NBC1) ELISA Kit Customized Service Offer
  1. "Cloning and functional expression of a human kidney Na+:HCO3-cotransporter."J. Biol. Chem. 272:19111-19114(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter."J. Biol. Chem. 273:17689-17695(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC)."Am. J. Physiol. 276:C576-C584(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and cloning of the Na/HCO3- cotransporter (NBC) in human corneal endothelium."Exp. Eye Res. 77:287-295(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-):Na(+) stoichiometry from 3:1 to 2:1 in murine proximal tubule cells."J. Physiol. (Lond.) 537:659-665(2001) [PubMed] [Europe PMC] [Abstract]
  8. ErratumJ. Physiol. (Lond.) 538:1003-1003(2002)
  9. "Expression of a sodium bicarbonate cotransporter in human parotid salivary glands."Arch. Oral Biol. 47:1-9(2002) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding."J. Physiol. (Lond.) 544:679-685(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Role of glycosylation in the renal electrogenic Na+-HCO3-cotransporter (NBCe1)."Am. J. Physiol. 284:F1199-F1206(2003) [PubMed] [Europe PMC] [Abstract]
  12. "Localization of NBC-1 variants in human kidney and renal cell carcinoma."Biochem. Biophys. Res. Commun. 310:1213-1218(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation."Biochemistry 42:755-765(2003) [PubMed] [Europe PMC] [Abstract]
  14. "Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter."Biochemistry 42:12321-12329(2003) [PubMed] [Europe PMC] [Abstract]
  15. "Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini."J. Physiol. (Lond.) 549:673-682(2003) [PubMed] [Europe PMC] [Abstract]
  16. "Expression of Na+/HCO3- co-transporter proteins (NBCs) in rat and human skeletal muscle."Acta Physiol. Scand. 182:69-76(2004) [PubMed] [Europe PMC] [Abstract]
  17. "Identification of a carboxyl-terminal motif essential for the targeting of Na+-HCO-3 cotransporter NBC1 to the basolateral membrane."J. Biol. Chem. 279:43190-43197(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells."J. Physiol. (Lond.) 559:55-65(2004) [PubMed] [Europe PMC] [Abstract]
  19. "Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration."Hum. Mol. Genet. 14:255-265(2005) [PubMed] [Europe PMC] [Abstract]
  20. "Critical amino acid residues involved in the electrogenic sodium-bicarbonate cotransporter kNBC1-mediated transport."J. Physiol. (Lond.) 565:717-730(2005) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities."Nat. Genet. 23:264-266(1999) [PubMed] [Europe PMC] [Abstract]
  23. "A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects."J. Biol. Chem. 279:52238-52246(2004) [PubMed] [Europe PMC] [Abstract]
  24. "Missense mutations in Na+:HCO3- cotransporter NBC1 show abnormal trafficking in polarized kidney cells: a basis of proximal renal tubular acidosis."Am. J. Physiol. 289:F61-F71(2005) [PubMed] [Europe PMC] [Abstract]
  25. "Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities."J. Am. Soc. Nephrol. 16:2270-2278(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Proximal renal tubular acidosis and ocular pathology: a novel missense mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter protein (NBCe1)."Mol. Vis. 12:324-330(2006) [PubMed] [Europe PMC] [Abstract]
  27. "Functional analysis of a novel missense NBC1 mutation and of other mutations causing proximal renal tubular acidosis."Pflugers Arch. 455:583-593(2008) [PubMed] [Europe PMC] [Abstract]