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Lymphocyte Specific Protein Tyrosine Kinase (LCK)

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YT16; p56lck; pp58lck; LSK; Leukocyte C-terminal Src kinase; Lymphocyte cell-specific protein-tyrosine kinase; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase

Lymphocyte Specific Protein Tyrosine Kinase (LCK)
CCC E373
HGNC 6524
MGI 96756
PubMed 1909593
RGD 2994
UniProt P06239
Wiki LCK
Lck is a protein that is found inside specialized cells of the immune system called lymphocytes. Lck is a tyrosine kinase, which phosphorylates tyrosine residues of certain proteins involved in the intracellular signaling pathways of these lymphocytes. It is a member of the Src family of tyrosine kinases. Lck is a 56-kilodalton protein. The N-terminal tail of Lck is myristoylated and palmitoylated, which tethers the protein to the plasma membrane of the cell. The protein furthermore contains a SH3 domain, a SH2 domain and in the C-terminal part the tyrosine kinase domain.The former is an autophosphorylation site and is linked to activation of the protein. The latter is phosphorylated by Csk, which inhibits Lck because the protein folds up and binds its own SH2 domain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lymphocyte Specific Protein Tyrosine Kinase (LCK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lymphocyte Specific Protein Tyrosine Kinase (LCK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lymphocyte Specific Protein Tyrosine Kinase (LCK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lymphocyte Specific Protein Tyrosine Kinase (LCK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lymphocyte Specific Protein Tyrosine Kinase (LCK) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lymphocyte Specific Protein Tyrosine Kinase (LCK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lymphocyte Specific Protein Tyrosine Kinase (LCK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lymphocyte Specific Protein Tyrosine Kinase (LCK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lymphocyte Specific Protein Tyrosine Kinase (LCK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lymphocyte Specific Protein Tyrosine Kinase (LCK) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Lymphocyte Specific Protein Tyrosine Kinase (LCK) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Lymphocyte Specific Protein Tyrosine Kinase (LCK) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Lymphocyte Specific Protein Tyrosine Kinase (LCK) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Lymphocyte Specific Protein Tyrosine Kinase (LCK) CLIA Kit Customized Service Offer
n/a ELISA Kit for Lymphocyte Specific Protein Tyrosine Kinase (LCK) ELISA Kit Customized Service Offer
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  14. "The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity."EMBO J. 11:2919-2924(1992) [PubMed] [Europe PMC] [Abstract]
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  20. "Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site."Oncogene 14:2619-2631(1997) [PubMed] [Europe PMC] [Abstract]
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  22. "Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells."J. Immunol. 169:2813-2817(2002) [PubMed] [Europe PMC] [Abstract]
  23. "Cluster analysis of an extensive human breast cancer cell line protein expression map database."Proteomics 2:212-223(2002) [PubMed] [Europe PMC] [Abstract]
  24. "LIME: a new membrane raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling."J. Exp. Med. 198:1453-1462(2003) [PubMed] [Europe PMC] [Abstract]
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  26. "Interaction of SAP-1, a transmembrane-type protein-tyrosine phosphatase, with the tyrosine kinase Lck. Roles in regulation of T cell function."J. Biol. Chem. 278:34854-34863(2003) [PubMed] [Europe PMC] [Abstract]
  27. "Unc119, a novel activator of Lck/Fyn, is essential for T cell activation."J. Exp. Med. 199:369-379(2004) [PubMed] [Europe PMC] [Abstract]
  28. "T cell activation-induced CrkII binding to the Zap70 protein tyrosine kinase is mediated by Lck-dependent phosphorylation of Zap70 tyrosine 315."J. Immunol. 175:8123-8132(2005) [PubMed] [Europe PMC] [Abstract]
  29. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  30. "Identification of substrates of human protein-tyrosine phosphatase PTPN22."J. Biol. Chem. 281:11002-11010(2006) [PubMed] [Europe PMC] [Abstract]
  31. "Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45."J. Immunol. 176:6615-6623(2006) [PubMed] [Europe PMC] [Abstract]
  32. "Ephrin-A1 stimulates migration of CD8+CCR7+ T lymphocytes."Eur. J. Immunol. 37:2326-2336(2007) [PubMed] [Europe PMC] [Abstract]
  33. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  34. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  35. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  36. "Src kinase phosphorylates RUNX3 at tyrosine residues and localizes the protein in the cytoplasm."J. Biol. Chem. 285:10122-10129(2010) [PubMed] [Europe PMC] [Abstract]
  37. "The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems."J. Leukoc. Biol. 87:691-701(2010) [PubMed] [Europe PMC] [Abstract]
  38. "RhoH modulates pre-TCR and TCR signalling by regulating LCK."Cell. Signal. 23:249-258(2011) [PubMed] [Europe PMC] [Abstract]
  39. "T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice."J. Clin. Invest. 121:4758-4774(2011) [PubMed] [Europe PMC] [Abstract]
  40. "Tyrosine phosphorylation of tau by the SRC family kinases lck and fyn."Mol. Neurodegener. 6:12-12(2011) [PubMed] [Europe PMC] [Abstract]
  41. "Feedback circuits monitor and adjust Basal lck-dependent events in T cell receptor signaling."Sci. Signal. 4:RA59-RA59(2011) [PubMed] [Europe PMC] [Abstract]
  42. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  43. "Role of herpes simplex virus VP11/12 tyrosine-based motifs in binding and activation of the Src family kinase Lck and recruitment of p85, Grb2, and Shc."J. Virol. 87:11276-11286(2013) [PubMed] [Europe PMC] [Abstract]
  44. "Structure of the regulatory domains of the Src-family tyrosine kinase Lck."Nature 368:764-769(1994) [PubMed] [Europe PMC] [Abstract]
  45. "The crystal structures of the SH2 domain of p56lck complexed with two phosphonopeptides suggest a gated peptide binding site."J. Mol. Biol. 246:344-355(1995) [PubMed] [Europe PMC] [Abstract]
  46. "Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0-A and 1.8-A resolution."J. Mol. Biol. 256:601-610(1996) [PubMed] [Europe PMC] [Abstract]
  47. "Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation."Nature 384:484-489(1996) [PubMed] [Europe PMC] [Abstract]
  48. "Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding."J. Biol. Chem. 273:20238-20242(1998) [PubMed] [Europe PMC] [Abstract]
  49. "Primary T-cell immunodeficiency with immunodysregulation caused by autosomal recessive LCK deficiency." J. Allergy Clin. Immunol. 130:1144-1152(2012) [PubMed] [Europe PMC] [Abstract]