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Divalent Metal Transporter 1 (DMT1)

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SLC11A2; DCT1; NRAMP2; Natural resistance-associated macrophage protein 2; Solute Carrier Family 11 Member 2,Proton-Coupled Divalent Metal Ion Transporters

Divalent Metal Transporter 1 (DMT1)
CCC E426
HGNC 10908
MGI 1345279
PubMed 22509377
RGD 3684
UniProt P49281
Wiki SLC11A2
The SLC11A2 gene encodes a divalent metal transporter (DMT1), which carries iron, manganese, cobalt, nickel, cadmium, lead, copper, and zinc. DMT1 participates in cellular iron absorption at the luminal surface of the duodenum as well as in other areas of the body. Predicted amino acid sequence analysis of the NRAMP2 polypeptide identified a polytopic membrane protein highly homologous to human NRAMP1, with 66% identical residues (80% overall homology), resulting in identical predicted secondary structure of the 2 proteins. Sequence conservation is particularly high in the predicted transmembrane domains (90%), suggesting that these regions play a key role in the structural and functional aspects common to both proteins. As opposed to its NRAMP1 counterpart, whose expression is restricted to phagocytic cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE426Hu01 Recombinant Divalent Metal Transporter 1 (DMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE426Hu21 Monoclonal Antibody to Divalent Metal Transporter 1 (DMT1) WB; IHC; ICC; IP.
PAE426Hu01 Polyclonal Antibody to Divalent Metal Transporter 1 (DMT1) WB; IHC; ICC; IP.
Assay Kits SEE426Hu ELISA Kit for Divalent Metal Transporter 1 (DMT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Divalent Metal Transporter 1 (DMT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Divalent Metal Transporter 1 (DMT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Divalent Metal Transporter 1 (DMT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Divalent Metal Transporter 1 (DMT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Divalent Metal Transporter 1 (DMT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE426Ra01 Recombinant Divalent Metal Transporter 1 (DMT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE426Ra21 Monoclonal Antibody to Divalent Metal Transporter 1 (DMT1) WB; IHC; ICC; IP.
PAE426Ra01 Polyclonal Antibody to Divalent Metal Transporter 1 (DMT1) WB; IHC; ICC; IP.
Assay Kits SEE426Ra ELISA Kit for Divalent Metal Transporter 1 (DMT1) Enzyme-linked immunosorbent assay for Antigen Detection.
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  12. "Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2."Blood 112:4268-4275(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons."Proc. Natl. Acad. Sci. U.S.A. 106:15489-15494(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membrane."Cell Biol. Int. 39:427-434(2015) [PubMed] [Europe PMC] [Abstract]
  15. "Evidence for mitochondrial localization of divalent metal transporter 1 (DMT1)."FASEB J. 28:2134-2145(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport."Nat. Struct. Mol. Biol. 21:990-996(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload."Blood 105:1337-1342(2005) [PubMed] [Europe PMC] [Abstract]
  18. "Microcytic anemia and hepatic iron overload in a child with compound heterozygous mutations in DMT1 (SCL11A2)."Blood 107:349-354(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Two new human DMT1 gene mutations in a patient with microcytic anemia, low ferritinemia, and liver iron overload."Blood 107:4168-4170(2006) [PubMed] [Europe PMC] [Abstract]
  20. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]