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Solute Carrier Family 24, Member 5 (SLC24A5)

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JSX; SHEP4; NCKX5; Na(+)/K(+)/Ca(2+)-exchange protein 5; Sodium/potassium/calcium exchanger 5

Solute Carrier Family 24, Member 5 (SLC24A5)
CCC E440
HGNC 20611
MGI 2677271
PubMed 16357253
UniProt Q71RS6
Wiki SLC24A5
SLC24A5 is a member of the potassium-dependent sodium/calcium exchanger family. Sequence variation in this gene has been associated with differences in skin pigmentation.The SLC24A5 gene is located on the long (q) arm of chromosome 15 on position 21.1, from base pair 46,200,461 to base pair 46,221,881.
Variations in the SLC24A5 gene are thought to explain between 25 and 38% of skin pigmentation variation between Black African and White European humans.Research led by cancer geneticist Keith Cheng and anthropologist Mark D. Shriver at Penn State University along with a number of other institutions discovered that the gene has two primary alleles that differ in only one nucleotide, changing the 111th amino acid from alanine to threonine.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 24, Member 5 (SLC24A5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 24, Member 5 (SLC24A5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 24, Member 5 (SLC24A5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 24, Member 5 (SLC24A5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 24, Member 5 (SLC24A5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Family 24, Member 5 (SLC24A5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Family 24, Member 5 (SLC24A5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Family 24, Member 5 (SLC24A5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Family 24, Member 5 (SLC24A5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Family 24, Member 5 (SLC24A5) ELISA Kit Customized Service Offer
  1. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans." Science 310:1782-1786(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."J. Proteome Res. 5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]
  5. "SLC24A5 encodes a trans-Golgi network protein with potassium-dependent sodium-calcium exchange activity that regulates human epidermal melanogenesis."J. Biol. Chem. 283:5486-5495(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Exome sequencing identifies SLC24A5 as a candidate gene for nonsyndromic oculocutaneous albinism."J. Invest. Dermatol. 133:1834-1840(2013) [PubMed] [Europe PMC] [Abstract]
  7. "A genomewide association study of skin pigmentation in a South Asian population."Am. J. Hum. Genet. 81:1119-1132(2007) [PubMed] [Europe PMC] [Abstract]