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Organic Cation Transporter 1 (OCT1)

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SLC22A1; HOCT1; Oct1_cds; Solute Carrier Family 22 Member 1

Organic Cation Transporter 1 (OCT1)
CCC E441
HGNC 10963
MGI 108111
PubMed 24117365
RGD 3224
UniProt O15245
Wiki SLC22A1
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. SLC22A1 is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. Widely expressed with high level in liver. Isoform 1 and isoform 2 are expressed in liver. Isoform 1, isoform 2, isoform 3 and isoform 4 are expressed in glial cell lines.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Organic Cation Transporter 1 (OCT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Cation Transporter 1 (OCT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Cation Transporter 1 (OCT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Cation Transporter 1 (OCT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Cation Transporter 1 (OCT1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Organic Cation Transporter 1 (OCT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Cation Transporter 1 (OCT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Cation Transporter 1 (OCT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Cation Transporter 1 (OCT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Cation Transporter 1 (OCT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Organic Cation Transporter 1 (OCT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Cation Transporter 1 (OCT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Cation Transporter 1 (OCT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Cation Transporter 1 (OCT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Cation Transporter 1 (OCT1) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of two human polyspecific organic cation transporters."DNA Cell Biol. 16:871-881(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and functional expression of a human liver organic cation transporter."Mol. Pharmacol. 51:913-921(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)."Ann. Hum. Genet. 63:473-482(1999) [PubMed] [Europe PMC] [Abstract]
  4. ErratumAnn. Hum. Genet. 64:267-267(2000)
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa)."J. Pharmacol. Exp. Ther. 286:354-361(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides."J. Pharmacol. Exp. Ther. 298:110-115(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Regulation of the human organic cation transporter hOCT1."J. Cell. Physiol. 201:420-428(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)."Biochem. Pharmacol. 70:1851-1860(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1."Drug Metab. Pharmacokinet. 20:379-386(2005) [PubMed] [Europe PMC] [Abstract]
  13. "The human organic cation transporter-1 gene is transactivated by hepatocyte nuclear factor-4alpha."J. Pharmacol. Exp. Ther. 317:778-785(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain."Neuropharmacology 50:941-952(2006) [PubMed] [Europe PMC] [Abstract]
  15. "The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells."Fundam. Clin. Pharmacol. 21:445-450(2007) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences."Pharmacogenetics 12:591-595(2002) [PubMed] [Europe PMC] [Abstract]
  18. "Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1."Proc. Natl. Acad. Sci. U.S.A. 100:5902-5907(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions."Biochem. Biophys. Res. Commun. 313:789-793(2004) [PubMed] [Europe PMC] [Abstract]
  20. "Seven novel single nucleotide polymorphisms in the human SLC22A1 gene encoding organic cation transporter 1 (OCT1)."Drug Metab. Pharmacokinet. 19:308-312(2004) [PubMed] [Europe PMC] [Abstract]