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Organic Anion Transporter 3 (OAT3)

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SLC22A8; Solute Carrier Family 22 Member 8

Organic Anion Transporter 3 (OAT3)
CCC E448
HGNC 10972
MGI 1336187
PubMed 23649425
RGD 632286
UniProt Q8TCC7
Wiki SLC22A8
Organic anion transporter 3 (OAT3), is involved in the transport and excretion of organic anions, some of which are drugs [e.g., penicillin G (benzylpenicillin), methotrexate (MTX), indomethacin (an NSAID), ciprofloxacin (a carboxyfluoroquinolone)], and some of which are pure toxicants. SLC22A8 (OAT3) is indirectly dependent on the inward sodium gradient, which is a driving force for reentry of dicarboxylates into the cytosol. Dicarboxylates, such as alpha-ketoglutarate generated within the cell, or recycled from the extracellular space, are used as exchange substrates to fuel the influx of organic anions against their concentration gradient. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of renal proximal tubule cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Organic Anion Transporter 3 (OAT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Anion Transporter 3 (OAT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Anion Transporter 3 (OAT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Anion Transporter 3 (OAT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Anion Transporter 3 (OAT3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Organic Anion Transporter 3 (OAT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Anion Transporter 3 (OAT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Anion Transporter 3 (OAT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Anion Transporter 3 (OAT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Anion Transporter 3 (OAT3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Organic Anion Transporter 3 (OAT3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Organic Anion Transporter 3 (OAT3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Organic Anion Transporter 3 (OAT3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Organic Anion Transporter 3 (OAT3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Organic Anion Transporter 3 (OAT3) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of two novel human renal organic anion transporters (hOAT1 and hOAT3)."Biochem. Biophys. Res. Commun. 255:508-514(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Gene expression levels and immunolocalization of organic ion transporters in the human kidney."J. Am. Soc. Nephrol. 13:866-874(2002) [PubMed] [Europe PMC] [Abstract]
  6. "Human organic anion transporter 3 (hOAT3) can operate as an exchanger and mediate secretory urate flux."Cell. Physiol. Biochem. 13:249-256(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Transport of the natural sweetener stevioside and its aglycone steviol by human organic anion transporter (hOAT1; SLC22A6) and hOAT3 (SLC22A8)."J. Pharmacol. Exp. Ther. 313:621-628(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular cloning and functional analyses of OAT1 and OAT3 from cynomolgus monkey kidney."Pharm. Res. 22:647-660(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Inhibition of oat3-mediated renal uptake as a mechanism for drug-drug interaction between fexofenadine and probenecid."Drug Metab. Dispos. 34:743-747(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics."Clin. Pharmacol. Ther. 73:554-565(2003) [PubMed] [Europe PMC] [Abstract]
  11. "The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics."Am. J. Physiol. 290:F905-F912(2006) [PubMed] [Europe PMC] [Abstract]