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Urate Transporter 1 (URAT1)

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SLC22A12; OAT4L; RST; Solute Carrier Family 22 Member 12,Organic Anion/Urate Transporter; Organic anion transporter 4-like; Urate anion exchanger 1; Renal-specific transporter

Urate Transporter 1 (URAT1)
CCC E451
HGNC 17989
MGI 1195269
PubMed 16837472
RGD 621628
UniProt Q96S37
Wiki SLC22A12
SLC22A12 is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene.Detected in kidney (at protein level). Detected in fetal and adult kidney. Detected in epithelial cells of proximal tubules in renal cortex.
Numerous single nucleotide polymorphisms of this gene are significantly associated with altered (increased or decreased) reabsorption of uric acid by the kidneys. Respectively, these altered rates of reabsorption contribute to hyperuricemia and hypouricemia.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE451Hu01 Recombinant Urate Transporter 1 (URAT1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE451Hu21 Monoclonal Antibody to Urate Transporter 1 (URAT1) WB; IHC; ICC; IP.
PAE451Hu01 Polyclonal Antibody to Urate Transporter 1 (URAT1) WB; IHC; ICC; IP.
Assay Kits SEE451Hu ELISA Kit for Urate Transporter 1 (URAT1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Urate Transporter 1 (URAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Urate Transporter 1 (URAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Urate Transporter 1 (URAT1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Urate Transporter 1 (URAT1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Urate Transporter 1 (URAT1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Urate Transporter 1 (URAT1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Urate Transporter 1 (URAT1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Urate Transporter 1 (URAT1) Polyclonal Antibody Customized Service Offer
Assay Kits SEE451Ra ELISA Kit for Urate Transporter 1 (URAT1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Molecular identification of a renal urate anion exchanger that regulates blood urate levels."Nature 417:447-452(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout."Rheumatology 46:215-219(2007) [PubMed] [Europe PMC] [Abstract]
  7. "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells."Kidney Int. 64:1733-1745(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate-anion exchanger URAT1 via its C terminus."J. Biol. Chem. 279:45942-45950(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Clinical and molecular analysis of patients with renal hypouricemia in Japan-influence of URAT1 gene on urinary urate excretion."J. Am. Soc. Nephrol. 15:164-173(2004) [PubMed] [Europe PMC] [Abstract]
  10. "A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese."Kidney Int. 66:935-944(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Mutations in human urate transporter 1 gene in presecretory reabsorption defect type of familial renal hypouricemia."J. Clin. Endocrinol. Metab. 90:2169-2174(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Mutational analysis of idiopathic renal hypouricemia in Korea."Pediatr. Nephrol. 20:886-890(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population."Arthritis Rheum. 54:292-300(2006) [PubMed] [Europe PMC] [Abstract]