≡

Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2)

[Edit]

SLC38A2; ATA2; SAT2; Amino Acid Transport System A2; Solute Carrier Family 38 Member 2; System A transporter 1; System N amino acid transporter 2

Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2)
CCC E506
HGNC 13448
MGI 1915010
PubMed 16365304
RGD 69420
UniProt Q96QD8
Wiki SLC38A2
The amino acid transport system A, named for its preference for alanine as substrate, is known to be present in most mammalian tissues. The characteristics of system A include sodium dependence, preference for short-chain neutral amino acids, such as alanine, serine, proline, and glutamine, as substrates, pH sensitivity, and transinhibition. Bulky hydrophobic amino acids, anionic amino acids, and cationic amino acids are excluded by the system. However, system A can be discriminated from other known transport systems for neutral amino acids by its unique ability to transport N-methylated amino acids. System A is defined as the component of sodium-dependent transport of any neutral amino acid that is inhibitable by the model substrate alpha-(methylamino)isobutyric acid (MeAIB).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sodium Coupled Neutral Amino Acid Transporter 2 (SNAT2) ELISA Kit Customized Service Offer
  1. "Primary structure, functional characteristics and tissue expression pattern of human ATA2, a subtype of amino acid transport system A."Biochim. Biophys. Acta 1467:1-6(2000) [PubMed] [Europe PMC] [Abstract]
  2. Thesis (2001), University of Goettingen, Germany
  3. "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:65-73(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Transcriptional control of the human sodium-coupled neutral amino acid transporter system A gene by amino acid availability is mediated by an intronic element."J. Biol. Chem. 279:3463-3471(2004) [PubMed] [Europe PMC] [Abstract]
  8. "SNAT2 silencing prevents the osmotic induction of transport system A and hinders cell recovery from hypertonic stress."FEBS Lett. 579:3376-3380(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Immunohistochemical localization of the amino acid transporter SNAT2 in the rat brain."Neuroscience 130:61-73(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Amino acid starvation induces the SNAT2 neutral amino acid transporter by a mechanism that involves eukaryotic initiation factor 2alpha phosphorylation and cap-independent translation."J. Biol. Chem. 281:17929-17940(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Localization of the Na(+)-coupled neutral amino acid transporter 2 in the cerebral cortex."Neuroscience 140:281-292(2006) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]