Multidrug And Toxin Extrusion Protein 2 (MATE2)

SLC47A2encodes a protein belonging to a family of transporters involved in excretion of toxic electrolytes, both endogenous and exogenous, through urine and bile. This transporter family shares homology with the bacterial MATE protein family responsible for drug resistance. This gene is one of two members of the MATE transporter family located near each other on chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

The multidrug efflux transporter NorM from V. parahaemolyticus which mediates resistance to multiple antimicrobial agents and its homologue from E. coli were identified in 1998. NorM seems to function as drug/sodium antiporter which is the first example of Na⁺-coupled multidrug efflux transporter discovered.