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Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1)

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OATPB; OATP2B1; OATP-B; SLC21A9; Solute Carrier Family 21 Member 9; Organic Anion Transporting Polypeptide B; Organic anion transporter polypeptide-related protein 2

Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1)
CCC E519
HGNC 10962
MGI 1351872
PubMed 21266523
RGD 621391
UniProt O94956
Wiki SLCO2B1
The predicted 709-amino acid SLC21A9 protein contains 8 membrane-spanning regions. SLC21A9 shares 42.8% amino acid sequence identity with a rat prostaglandin transporter across 678 residues. RT-PCR followed by ELISA detected SLC21A9 expression in all human tissues examined, with the highest expression in liver, lower expression in lung, ovary, brain, heart, kidney, pancreas, spleen, and testis, and lowest expression in skeletal muscle. OATPB mRNA levels were measured in isolated trophoblasts under culture conditions that promoted syncytia formation. Real-time quantitative PCR estimated an 8-fold increase in OATPB expression on differentiation to syncytia. Pregnenolone sulfate partially inhibited OATPB-mediated transport of estrone-3-sulfate in an oocyte expression system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Solute Carrier Organic Anion Transporter Family, Member 2B1 (SLCO2B1) ELISA Kit Customized Service Offer
  1. "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family."Biochem. Biophys. Res. Commun. 273:251-260(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1."Mol. Pharmacol. 70:806-817(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Transport function and transcriptional regulation of a liver-enriched human organic anion transporting polypeptide 2B1 transcriptional start site variant."Mol. Pharmacol. 83:1218-1228(2013) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]