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Collectin Kidney 1 (CLK1)

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CL-K1; COLEC11; Collectin Subfamily Member 11

Collectin Kidney 1 (CLK1)
CCC E524
HGNC 17213
MGI 1918943
PubMed 23519612
UniProt Q9BWP8
Wiki CLK1
COLEC11 is a member of the collectin family of C-type lectins, which contain a collagen-like domain and a carbohydrate recognition domain, and play a role in host-defense (Keshi et al., 2006).COLEC11 binds a variety of microbial saccharides including LPS from E. coli and Klebsiella pneumoniae, as well as S. cerevisiae mannan.
By EST database screening using the carbohydrate recognition domain (CRD) of human liver collectin, CLL1 (COLEC10), followed by 5-prime RACE of human kidney cDNA libraries, Keshi et al. (2006) cloned COLEC11, which they called CLK1. The deduced 271-amino acid COLEC11 protein contains an N-terminal region with a cysteine residue, a collagen-like sequence, a neck region, a CRD, and a predicted signal peptide of 25-amino acids; the mature predicted protein consists of 246 amino acids.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collectin Kidney 1 (CLK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collectin Kidney 1 (CLK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collectin Kidney 1 (CLK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collectin Kidney 1 (CLK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collectin Kidney 1 (CLK1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Collectin Kidney 1 (CLK1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Collectin Kidney 1 (CLK1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Collectin Kidney 1 (CLK1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Collectin Kidney 1 (CLK1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Collectin Kidney 1 (CLK1) ELISA Kit Customized Service Offer
  1. "Identification and characterization of a novel human collectin CL-K1."Microbiol. Immunol. 50:1001-1013(2006) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  9. "Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome." Nat. Genet. 43:197-203(2011) [PubMed] [Europe PMC] [Abstract]