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Ankyrin 3, Node Of Ranvier (ANK3)

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Ankyrin-G

Ankyrin 3, Node Of Ranvier (ANK3)
CCC E526
HGNC 494
MGI 88026
PubMed 23390136
RGD 620157
UniProt Q12955
Wiki ANK3
Ankyrin-3 is an immunologically distinct gene product from ankyrins ANK1 and ANK2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Alternatively spliced variants may be expressed in other tissues. Although multiple transcript variants encoding several different isoforms have been found for this gene, the full-length nature of only two have been characterized.
ANK3 is a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE526Hu01 Recombinant Ankyrin 3, Node Of Ranvier (ANK3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Ankyrin 3, Node Of Ranvier (ANK3) Monoclonal Antibody Customized Service Offer
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n/a ELISA Kit for Ankyrin 3, Node Of Ranvier (ANK3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin 3, Node Of Ranvier (ANK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin 3, Node Of Ranvier (ANK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin 3, Node Of Ranvier (ANK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin 3, Node Of Ranvier (ANK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin 3, Node Of Ranvier (ANK3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ankyrin 3, Node Of Ranvier (ANK3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ankyrin 3, Node Of Ranvier (ANK3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ankyrin 3, Node Of Ranvier (ANK3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ankyrin 3, Node Of Ranvier (ANK3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ankyrin 3, Node Of Ranvier (ANK3) ELISA Kit Customized Service Offer
  1. "AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier."J. Biol. Chem. 270:2352-2359(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of a small cytoplasmic ankyrin (AnkG119) in the kidney and muscle that binds beta I sigma spectrin and associates with the Golgi apparatus."J. Cell Biol. 133:819-830(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells."J. Biol. Chem. 280:8221-8228(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Novel interactions of ankyrins-G at the costameres: the muscle-specific Obscurin/Titin-Binding-related Domain (OTBD) binds plectin and filamin C."Exp. Cell Res. 317:724-736(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  13. "Ankyrin-3 is a novel binding partner of the voltage-gated potassium channel Kv1.1 implicated in renal magnesium handling."Kidney Int. 85:94-102(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Mutations of ANK3 identified by exome sequencing are associated with autism susceptibility."Hum. Mutat. 33:1635-1638(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Homozygous and heterozygous disruptions of ANK3: at the crossroads of neurodevelopmental and psychiatric disorders." Hum. Mol. Genet. 22:1960-1970(2013) [PubMed] [Europe PMC] [Abstract]