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Gasdermin B (GSDMB)

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GSDML; Gasdermin-Like

Gasdermin B (GSDMB)
CCC E530
HGNC 23690
PubMed 22732088
UniProt Q8TAX9
GSDMB encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.
GSDML is relatively divergent from other members of the GSDM family in human and rodents, and it lacks the central leucine zipper found in GSDM1. No GSDML ortholog was identified in the rat and mouse genomes. By database and sequence analysis, Tamura et al. (2007) identified several members of the GSDM family, including GSDMB. Tamura et al. (2007) also failed to identify a GSDMB ortholog in rat and mouse.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Gasdermin B (GSDMB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Gasdermin B (GSDMB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gasdermin B (GSDMB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gasdermin B (GSDMB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gasdermin B (GSDMB) ELISA Kit Customized Service Offer
  1. "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."Genome Res. 11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Large-scale cDNA transfection screening for genes related to cancer development and progression." Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon."Int. J. Oncol. 24:757-763(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Transcriptional control of the HERV-H LTR element of the GSDML gene in human tissues and cancer cells."Arch. Virol. 151:1985-1994(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma."Cancer Sci. 98:740-746(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner."Genomics 89:618-629(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Differential expression and localisation of gasdermin-like (GSDML), a novel member of the cancer-associated GSDMDC protein family, in neoplastic and non-neoplastic gastric, hepatic, and colon tissues."Pathology 40:13-24(2008) [PubMed] [Europe PMC] [Abstract]
  12. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]