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Gasdermin A (GSDMA)

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GSDM; GSDM1; FKSG9; Gasdermin; Gasdermin 1

Gasdermin A (GSDMA)
CCC E531
HGNC 13311
MGI 1889509
PubMed 21337730
RGD 1592062
UniProt Q96QA5
GSDM showed apoptotic activity upon expression in a human gastric cancer cell line. LMO1, RUNX3), and TGF-beta receptor II (TGFBR2) were coexpressed with GSDM in pit cells, and both LMO1 and RUNX3 bound to the GSDM promoter in vitro. TGF-beta (TGFB1) upregulated LMO1 and GSDM expression and induced apoptosis, and induction of apoptosis was inhibited by suppression of LMO1, RUNX3, and GSDM expression. Saeki et al. (2007) concluded that GSDM is a component of TGF-beta signaling that induces apoptosis in gastric pit cells.The deduced 446-amino acid protein contains a leucine zipper motif. Northern blot analysis detected Gsdm1 expression in mouse stomach, skin, and esophagus, but not in other tissues examined. Northern blot analysis of human tissues detected GSDM1 expression in stomach only.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE531Hu01 Recombinant Gasdermin A (GSDMA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE531Hu01 Polyclonal Antibody to Gasdermin A (GSDMA) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Gasdermin A (GSDMA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gasdermin A (GSDMA) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE531Mu01 Recombinant Gasdermin A (GSDMA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Gasdermin A (GSDMA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gasdermin A (GSDMA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gasdermin A (GSDMA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gasdermin A (GSDMA) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE531Ra01 Recombinant Gasdermin A (GSDMA) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Gasdermin A (GSDMA) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Gasdermin A (GSDMA) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Gasdermin A (GSDMA) CLIA Kit Customized Service Offer
n/a ELISA Kit for Gasdermin A (GSDMA) ELISA Kit Customized Service Offer
  1. "GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling."Oncogene 26:6488-6498(2007) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Gasdermin (Gsdm) localizing to mouse chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells."Mamm. Genome 11:718-724(2000) [PubMed] [Europe PMC] [Abstract]
  6. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]