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Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM)

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CDON; CDO; CDON1; HPE11

Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM)
CCC E532
HGNC 17104
MGI 1926387
PubMed 21802063
RGD 708433
UniProt Q4KMG0
Wiki CDON
CDON and BOC are cell surface receptors of the immunoglobulin (Ig)/fibronectin type III (FNIII) repeat family involved in myogenic differentiation. CDON and BOC are coexpressed during development, form complexes with each other in a cis fashion, and are related to each other in their ectodomains, but each has a unique long cytoplasmic tail.
The 1,225-amino acid human protein and the rat protein have identical domain structures in their extracellular regions and highly related intracellular regions. The consensus sequences of the Ig- and FNIII-like domains are conserved, as are the 10 N-glycosylation sites. Except for the signal sequence, which was absent from the human cDNAs cloned, human CDON shares 81% overall amino acid identity with rat Cdon.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE532Hu01 Recombinant Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE532Ra01 Recombinant Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Adhesion Molecule Related/Down Regulated By Oncogenes (ORCAM) ELISA Kit Customized Service Offer
  1. "CDO: an oncogene-, serum-, and anchorage-regulated member of the Ig/fibronectin type III repeat family."J. Cell Biol. 138:203-213(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla."Nature 455:979-983(2008) [PubMed] [Europe PMC] [Abstract]
  5. "All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner."J. Biol. Chem. 285:24584-24590(2010) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in CDON, encoding a hedgehog receptor, result in holoprosencephaly and defective interactions with other hedgehog receptors."Am. J. Hum. Genet. 89:231-240(2011) [PubMed] [Europe PMC] [Abstract]