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T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1)

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SCL; TCL5; BHLHA17; Stem cell protein; T-Cell Leukemia/Lymphoma Protein 5; Class A basic helix-loop-helix protein 17

T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1)
CCC E568
HGNC 11556
MGI 98480
PubMed 22982397
RGD 1306748
UniProt P17542
Wiki TAL1
Begley et al. (1989) studied a leukemic stem cell line capable of differentiating into either myeloid or lymphoid cells that carried a t(1;14)(p33;q11) translocation. The chromosome 1 region involved in the breakpoint was the site of transcriptional activity apparently occurring only in hematopoietic tissues.
Begley et al. (1989) concluded that the translocation may identify a gene on chromosome 1 that is important for hematopoietic development and oncogenesis, and they suggested the gene designation SCL. Chen et al. (1990) concluded that the TAL1 gene encodes a helix-loop-helix protein with homology to LYL1, which is also involved in malignant development of lymphocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE568Hu01 Recombinant T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE568Hu01 Polyclonal Antibody to T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for T-Cell Acute Lymphocytic Leukemia Protein 1 (TAL1) ELISA Kit Customized Service Offer
  1. "The SCL gene is formed from a transcriptionally complex locus."Mol. Cell. Biol. 10:6426-6435(1990) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  3. "Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia."J. Exp. Med. 172:1403-1408(1990) [PubMed] [Europe PMC] [Abstract]
  4. "The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif."Proc. Natl. Acad. Sci. U.S.A. 86:10128-10132(1989) [PubMed] [Europe PMC] [Abstract]
  5. "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein."EMBO J. 9:415-424(1990) [PubMed] [Europe PMC] [Abstract]
  6. "The SCL gene product: a positive regulator of erythroid differentiation."EMBO J. 11:4073-4081(1992) [PubMed] [Europe PMC] [Abstract]
  7. "Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues."Oncogene 8:677-683(1993) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]