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B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L)

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DLNB11; B-cell lymphoma 9-like protein

B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L)
CCC E580
HGNC 23688
MGI 1933114
PubMed 22109522
RGD 1309096
UniProt Q86UU0
Bcl9L has a nuclear localization signal, but no signal peptide or transmembrane domain. The deduced mouse protein shares 94% identity with human BCL9L. In silico analysis of human mRNAs indicated that BCL9L is expressed in fetal brain, adult lung, amygdala, eye, and prostate, as well as in several types of tumors. RNA interference of BCL9-2 in carcinoma cells induced an epithelial phenotype and translocated beta-catenin from the nucleus to the cell membrane. The switch between the adhesive and transcriptional functions of beta-catenin was modulated by tyrosine phosphorylation of beta-catenin, which favored BCL9-2 binding and precluded interaction with alpha-catenin. During zebrafish embryogenesis, Bcl9-2 acted in the Wnt8 signaling pathway and regulated mesoderm patterning.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) Polyclonal Antibody Customized Service Offer
Assay Kits SEE580Hu ELISA Kit for B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) CLIA Kit Customized Service Offer
n/a ELISA Kit for B-Cell CLL/Lymphoma 9 Like Protein (Bcl9L) ELISA Kit Customized Service Offer
  1. "Essential role of BCL9-2 in the switch between beta-catenin's adhesive and transcriptional functions."Genes Dev. 18:2225-2230(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification and characterization of human BCL9L gene and mouse Bcl9l gene in silico."Int. J. Mol. Med. 12:643-649(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Crystal structure of a beta-catenin/BCL9/Tcf4 complex."Mol. Cell 24:293-300(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Up-regulation of a BCL9-related beta-catenin-binding protein, B9L, in different stages of sporadic colorectal adenoma."Cancer Sci. 98:83-87(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers."Cancer Sci. 98:484-490(2007) [PubMed] [Europe PMC] [Abstract]
  10. "BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling."Mech. Dev. 124:59-67(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]