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Ubiquitin Conjugating Enzyme E2C (UBE2C)

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UBCH10; Ubiquitin carrier protein C; Ubiquitin-protein ligase C

Ubiquitin Conjugating Enzyme E2C (UBE2C)
CCC E594
HGNC 15937
MGI 1915862
PubMed 21556051
RGD 1305382
UniProt O00762
Wiki UBE2C
Ubiquitin-conjugating enzyme E2 C is a protein encoded by the UBE2C gene.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE594Hu01 Recombinant Ubiquitin Conjugating Enzyme E2C (UBE2C) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE594Hu01 Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2C (UBE2C) WB; ICC/IF
MAE594Hu21 Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2C (UBE2C) WB; IHC; ICC; IP.
Assay Kits SEE594Hu ELISA Kit for Ubiquitin Conjugating Enzyme E2C (UBE2C) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2C (UBE2C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2C (UBE2C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2C (UBE2C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2C (UBE2C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2C (UBE2C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2C (UBE2C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2C (UBE2C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2C (UBE2C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2C (UBE2C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2C (UBE2C) ELISA Kit Customized Service Offer
  1. "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase."Proc. Natl. Acad. Sci. U.S.A. 94:2362-2367(1997) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
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  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit."Nat. Cell Biol. 11:1363-1369(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Identification of a physiological E2 module for the human anaphase-promoting complex."Proc. Natl. Acad. Sci. U.S.A. 106:18213-18218(2009) [PubMed] [Europe PMC] [Abstract]
  9. "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."J. Biol. Chem. 285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10."J. Biol. Chem. 277:21913-21921(2002) [PubMed] [Europe PMC] [Abstract]