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Ubiquitin Conjugating Enzyme E2L3 (UBE2L3)

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L-UBC; E2-F1; UBCH7; UbcM4; Ubiquitin carrier protein L3; Ubiquitin-conjugating enzyme E2-F1; Ubiquitin-protein ligase L3

Ubiquitin Conjugating Enzyme E2L3 (UBE2L3)
CCC E602
HGNC 12488
MGI 109240
PubMed 23933584
RGD 1308361
UniProt P68036
Wiki HIP2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s).
Ubiquitin-conjugating enzyme E2 L3 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE602Hu01 Recombinant Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE602Hu21 Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) WB; IHC; ICC; IP.
PAE602Hu01 Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) WB; IHC; ICC; IP.
Assay Kits SEE602Hu ELISA Kit for Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) Enzyme-linked immunosorbent assay for Antigen Detection.
SCE602Hu CLIA Kit for Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) Chemiluminescent immunoassay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2L3 (UBE2L3) ELISA Kit Customized Service Offer
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  10. "Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase."Nat. Genet. 25:302-305(2000) [PubMed] [Europe PMC] [Abstract]
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  14. "The ubiquitin-conjugating enzyme UBCH7 acts as a coactivator for steroid hormone receptors."Mol. Cell. Biol. 24:8716-8726(2004) [PubMed] [Europe PMC] [Abstract]
  15. "The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis."FEBS Lett. 580:940-947(2006) [PubMed] [Europe PMC] [Abstract]
  16. "UbcH7 interacts with the glucocorticoid receptor and mediates receptor autoregulation."J. Endocrinol. 190:621-629(2006) [PubMed] [Europe PMC] [Abstract]
  17. "NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase."J. Immunol. 176:6454-6463(2006) [PubMed] [Europe PMC] [Abstract]
  18. "The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains."Leukemia 23:1480-1489(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Novel control of S phase of the cell cycle by ubiquitin-conjugating enzyme H7."Mol. Biol. Cell 20:1-9(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  21. "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."J. Biol. Chem. 285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids."Nature 474:105-108(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade."Science 286:1321-1326(1999) [PubMed] [Europe PMC] [Abstract]
  25. "Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases."Cell 102:533-539(2000) [PubMed] [Europe PMC] [Abstract]