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Ubiquitin Conjugating Enzyme E2L6 (UBE2L6)

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UBCH8; RIG-B; Retinoic acid-induced gene B protein; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6; Ubiquitin/ISG15-conjugating enzyme E2 L6

Ubiquitin Conjugating Enzyme E2L6 (UBE2L6)
CCC E607
HGNC 12490
MGI 1914500
PubMed 15670748
RGD 1307960
UniProt O14933
Wiki UBE2L6
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s).
Ubiquitin/ISG15-conjugating enzyme E2 L6 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.Present in natural killer cells (at protein level).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ubiquitin Conjugating Enzyme E2L6 (UBE2L6) ELISA Kit Customized Service Offer
  1. "Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12."Cytogenet. Cell Genet. 89:137-140(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity."J. Biol. Chem. 272:13548-13554(1997) [PubMed] [Europe PMC] [Abstract]
  6. "The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein."Proc. Natl. Acad. Sci. U.S.A. 101:7578-7582(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity."Biochem. Biophys. Res. Commun. 281:706-713(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme."J. Biochem. 138:711-719(2005) [PubMed] [Europe PMC] [Abstract]
  9. "The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis."FEBS Lett. 580:940-947(2006) [PubMed] [Europe PMC] [Abstract]
  10. "NK lytic-associated molecule, involved in NK cytotoxic function, is an E3 ligase."J. Immunol. 176:6454-6463(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation."Leukemia 24:1412-1421(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Crystal structure of Ubch8."Submitted (MAR-2005) to the PDB data bank
  15. "The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site."Biochemistry 48:12169-12179(2009) [PubMed] [Europe PMC] [Abstract]