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Cell Division Cycle Protein 37 (CDC37)

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p50Cdc37; Hsp90 chaperone protein kinase-targeting subunit; Hsp90 co-chaperone Cdc37

Cell Division Cycle Protein 37 (CDC37)
CCC E612
HGNC 1735
MGI 109531
PubMed 22674575
RGD 71006
UniProt Q16543
Wiki CDC37
Hsp90 co-chaperone Cdc37 is a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK, as well as eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
Human CDC37 contains 378 amino acids and shares 45% and 25% amino acid identity with Drosophila and S. cerevisiae CDC37, respectively. Mutations in yeast CDC37 cause cell cycle arrest in G1 phase, and yeast CDC37 is required for the association of CDC28 and cyclin and for the activation of CDC28.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 37 (CDC37) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 37 (CDC37) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 37 (CDC37) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 37 (CDC37) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 37 (CDC37) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 37 (CDC37) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 37 (CDC37) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 37 (CDC37) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 37 (CDC37) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 37 (CDC37) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 37 (CDC37) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 37 (CDC37) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 37 (CDC37) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 37 (CDC37) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 37 (CDC37) ELISA Kit Customized Service Offer
  1. "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4."Genes Dev. 10:1491-1502(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Physical interaction of mammalian CDC37 with CDK4."J. Biol. Chem. 271:22030-22034(1996) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Interaction between Cdc37 and Cdk4 in human cells."Oncogene 14:1999-2004(1997) [PubMed] [Europe PMC] [Abstract]
  5. "Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells."Oncogene 16:603-611(1998) [PubMed] [Europe PMC] [Abstract]
  6. "p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules."Biochemistry 39:7631-7644(2000) [PubMed] [Europe PMC] [Abstract]
  7. "Hsp90 regulates p50(cdc37) function during the biogenesis of the active conformation of the heme-regulated eIF2 alpha kinase."J. Biol. Chem. 276:206-214(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Functional interaction of human Cdc37 with the androgen receptor but not with the glucocorticoid receptor."J. Biol. Chem. 276:5814-5820(2001) [PubMed] [Europe PMC] [Abstract]
  9. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation."Nucleic Acids Res. 35:E109-E109(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]