≡

Cyclin Dependent Kinase 14 (CDK14)

[Edit]

PFTK1; PFTAIRE1; Serine/Threonine-Protein Kinase PFTAIRE-1; Cell division protein kinase 14

Cyclin Dependent Kinase 14 (CDK14)
CCC E619
HGNC 8883
MGI 894318
PubMed 22922871
RGD 1305544
UniProt O94921
The deduced 469-amino acid protein contains 2 predicted nuclear localization signals and a number of protein kinase superfamily subdomains including a conserved ATP binding region, a serine/threonine kinase signature motif, several conserved phosphorylation sites, and the PFTAIRE motif that is similar to the conserved Cdk motif PSTAIRE.
PFTK1 shares 95% amino acid sequence identity with the mouse ortholog, and 61% and 53% identity with the catalytic regions of PCTAIRE1 (PCTK1) and CDC2, respectively. Northern blot analysis detected a 6-kb PFTK1 transcript at highest levels in brain, pancreas, kidney, heart, testis, and ovary, and at lower levels in placenta, lung, liver, skeletal muscle, prostate, small intestine, colon, and peripheral blood leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE619Hu01 Recombinant Cyclin Dependent Kinase 14 (CDK14) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE619Hu01 Polyclonal Antibody to Cyclin Dependent Kinase 14 (CDK14) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 14 (CDK14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 14 (CDK14) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 14 (CDK14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 14 (CDK14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 14 (CDK14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 14 (CDK14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 14 (CDK14) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 14 (CDK14) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 14 (CDK14) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 14 (CDK14) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 14 (CDK14) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 14 (CDK14) ELISA Kit Customized Service Offer
  1. "Identification and cellular localization of human PFTAIRE1."Gene 267:165-172(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 7: DNA sequence and biology." Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "KIAA0202, a human septin family member, interacting with hPFTAIRE1."Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 34:520-525(2002) [PubMed] [Europe PMC] [Abstract]
  8. "A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins."Cell Res. 16:539-547(2006) [PubMed] [Europe PMC] [Abstract]
  9. "An RNA interference-based screen identifies MAP4K4/NIK as a negative regulator of PPARgamma, adipogenesis, and insulin-responsive hexose transport."Proc. Natl. Acad. Sci. U.S.A. 103:2087-2092(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Functional characterization of human PFTK1 as a cyclin-dependent kinase."Proc. Natl. Acad. Sci. U.S.A. 104:9248-9253(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Cell cycle control of wnt receptor activation."Dev. Cell 17:788-799(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Cyclin Y, a novel membrane-associated cyclin, interacts with PFTK1."FEBS Lett. 583:2171-2178(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Patterns of somatic mutation in human cancer genomes." Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]