≡

Cyclin Dependent Kinase 16 (CDK16)

[Edit]

PCTK1; PCTAIRE; PCTAIRE1; PCTGAIRE; Serine/Threonine-Protein Kinase PCTAIRE-1; PCTAIRE-motif protein kinase 1; Cell division protein kinase 16

Cyclin Dependent Kinase 16 (CDK16)
CCC E620
HGNC 8749
MGI 97516
PubMed 22184064
RGD 620584
UniProt Q00536
CDK16 belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells. This gene is thought to escape X inactivation. Two transcript variants encoding the same protein have been found for this gene.
The 3 PCTAIRE kinases are 65% identical to one another (80% within the catalytic domain). PCTAIRE1 is ubiquitously expressed with the highest levels detected in the brain and testis. Human PCTAIRE cDNAs do not complement yeast cdc28 mutants and show other differences, suggesting that PCTAIRE kinases have different cellular functions from those described for CDC2.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE620Hu01 Recombinant Cyclin Dependent Kinase 16 (CDK16) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE620Hu21 Monoclonal Antibody to Cyclin Dependent Kinase 16 (CDK16) WB; IHC; ICC; IP.
PAE620Hu01 Polyclonal Antibody to Cyclin Dependent Kinase 16 (CDK16) WB
Assay Kits SEE620Hu ELISA Kit for Cyclin Dependent Kinase 16 (CDK16) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 16 (CDK16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 16 (CDK16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 16 (CDK16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 16 (CDK16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 16 (CDK16) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cyclin Dependent Kinase 16 (CDK16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cyclin Dependent Kinase 16 (CDK16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cyclin Dependent Kinase 16 (CDK16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cyclin Dependent Kinase 16 (CDK16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cyclin Dependent Kinase 16 (CDK16) ELISA Kit Customized Service Offer
  1. "A family of human cdc2-related protein kinases."EMBO J. 11:2909-2917(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase."Cell. Signal. 24:2085-2094(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Brain-selective kinase 2 (BRSK2) phosphorylation on PCTAIRE1 negatively regulates glucose-stimulated insulin secretion in pancreatic beta-cells."J. Biol. Chem. 287:30368-30375(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis."Mol. Cell. Biol. 32:868-879(2012) [PubMed] [Europe PMC] [Abstract]
  15. "Crystal structure of the PCTAIRE1 kinase in complex with indirubin e804."Submitted (JUN-2010) to the PDB data bank