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Guanylate Binding Protein 1, Interferon Inducible (GBP1)

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GTP-binding protein 1; Guanine nucleotide-binding protein 1

Guanylate Binding Protein 1, Interferon Inducible (GBP1)
CCC E637
HGNC 4182
MGI 102772
PubMed 23633952
RGD 621810
UniProt P32455
Wiki GBP1
Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.
All GBPs, including GBP1, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. GBP1, GBP2, and GBP5 contain a C-terminal CaaX isoprenylation motif. EST database analysis showed wide expression of GBP1 in human tissues.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE637Hu01 Recombinant Guanylate Binding Protein 1, Interferon Inducible (GBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE637Hu01 Polyclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) WB; IHC; ICC; IP.
Assay Kits SEE637Hu ELISA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE637Mu01 Recombinant Guanylate Binding Protein 1, Interferon Inducible (GBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Guanylate Binding Protein 1, Interferon Inducible (GBP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) ELISA Kit Customized Service Offer

Organism species: Sus scrofa; Porcine (Pig)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE637Po01 Recombinant Guanylate Binding Protein 1, Interferon Inducible (GBP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE637Po01 Polyclonal Antibody to Guanylate Binding Protein 1, Interferon Inducible (GBP1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Guanylate Binding Protein 1, Interferon Inducible (GBP1) ELISA Kit Customized Service Offer
  1. "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP."Mol. Cell. Biol. 11:4717-4725(1991) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1."J. Leukoc. Biol. 60:423-431(1996) [PubMed] [Europe PMC] [Abstract]
  6. "Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor."Proc. Natl. Acad. Sci. U.S.A. 102:8680-8685(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis."Am. J. Pathol. 169:1088-1099(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Unique features of different members of the human guanylate-binding protein family."J. Interferon Cytokine Res. 27:44-52(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner."PLoS ONE 5:E14246-E14246(2010) [PubMed] [Europe PMC] [Abstract]
  11. "A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication."FASEB J. 26:1290-1300(2012) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins."Nature 403:567-571(2000) [PubMed] [Europe PMC] [Abstract]
  13. "Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism."EMBO J. 19:4555-4564(2000) [PubMed] [Europe PMC] [Abstract]
  14. "How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP."Nature 440:101-104(2006) [PubMed] [Europe PMC] [Abstract]