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FK506 Binding Protein 3 (FKBP3)

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FKBP-25; Rotamase; 25 kDa FK506-binding protein; Immunophilin FKBP25; Rapamycin-selective 25 kDa immunophilin; Peptidyl-prolyl cis-trans isomerase FKBP3

FK506 Binding Protein 3 (FKBP3)
CCC E643
HGNC 3719
MGI 1353460
PubMed 19166840
RGD 1304992
UniProt Q00688
Wiki FKBP3
FK506-binding protein 3 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
Hung and Schreiber (1992) isolated a cDNA for FKBP25 from a human hippocampal cDNA library by oligonucleotide screening. The nucleotide sequence revealed an open reading frame that encodes a 224-amino acid polypeptide. Human FKBP25 shows 97% amino acid identity with bovine protein and 62% homology with human FKBP12.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE643Hu01 Recombinant FK506 Binding Protein 3 (FKBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE643Hu01 Polyclonal Antibody to FK506 Binding Protein 3 (FKBP3) WB; IHC; ICC; IP.
LAE643Hu71 Biotin-Linked Polyclonal Antibody to FK506 Binding Protein 3 (FKBP3) WB; IHC; ICC.
LAE643Hu81 FITC-Linked Polyclonal Antibody to FK506 Binding Protein 3 (FKBP3) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for FK506 Binding Protein 3 (FKBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 3 (FKBP3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE643Mu01 Recombinant FK506 Binding Protein 3 (FKBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE643Mu01 Polyclonal Antibody to FK506 Binding Protein 3 (FKBP3) WB; IHC; ICC; IP.
LAE643Mu71 Biotin-Linked Polyclonal Antibody to FK506 Binding Protein 3 (FKBP3) WB; IHC; ICC.
LAE643Mu81 FITC-Linked Polyclonal Antibody to FK506 Binding Protein 3 (FKBP3) WB; IHC; ICC; IF.
Assay Kits n/a CLIA Kit for FK506 Binding Protein 3 (FKBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 3 (FKBP3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FK506 Binding Protein 3 (FKBP3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FK506 Binding Protein 3 (FKBP3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FK506 Binding Protein 3 (FKBP3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FK506 Binding Protein 3 (FKBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 3 (FKBP3) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE643Bo01 Recombinant FK506 Binding Protein 3 (FKBP3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE643Bo01 Polyclonal Antibody to FK506 Binding Protein 3 (FKBP3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for FK506 Binding Protein 3 (FKBP3) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 3 (FKBP3) ELISA Kit Customized Service Offer
  1. "Isolation of a human cDNA encoding a 25 kDa FK-506 and rapamycin binding protein."Biochem. Biophys. Res. Commun. 185:298-303(1992) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA cloning of a human 25 kDa FK506 and rapamycin binding protein."Biochem. Biophys. Res. Commun. 184:733-738(1992) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25."J. Biol. Chem. 267:10942-10945(1992) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Structure of the human 25 kDa FK506 binding protein complexed with rapamycin."J. Am. Chem. Soc. 118:1231-1232(1996)