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FK506 Binding Protein 6 (FKBP6)

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FKBP36; Peptidylprolyl Cis-Trans Isomerase; Rotamase; Immunophilin FKBP36; 36 kDa FK506-binding protein; Inactive peptidyl-prolyl cis-trans isomerase FKBP6

FK506 Binding Protein 6 (FKBP6)
CCC E646
HGNC 3722
MGI 2137612
PubMed 16983454
RGD 1308926
UniProt O75344
Wiki FKBP6
FKBP6 shows structural homology to FKBP immunophilins, which bind to the immunosuppressants FK506 and rapamycin.FKBP6 is essential for homologous chromosome pairing in meiosis during spermatogenesis. Targeted inactivation of FKBP6 in mice results in infertile males, but apparently normal females.The FKBP6 gene has 9 exons and is oriented in a 5-prime to 3-prime direction from centromere to telomere. FKBP6 is completely contained within a 35-kb cosmid; the DNA corresponding to the insert of this cosmid was deleted in 40 of 40 WBS individuals. The predicted 327-amino acid FKBP6 protein shows structural homology to FKBP immunophilins, which are cellular receptors for the immunosuppressive drugs FK506 and rapamycin.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FK506 Binding Protein 6 (FKBP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FK506 Binding Protein 6 (FKBP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FK506 Binding Protein 6 (FKBP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FK506 Binding Protein 6 (FKBP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 6 (FKBP6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FK506 Binding Protein 6 (FKBP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FK506 Binding Protein 6 (FKBP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FK506 Binding Protein 6 (FKBP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FK506 Binding Protein 6 (FKBP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 6 (FKBP6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FK506 Binding Protein 6 (FKBP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FK506 Binding Protein 6 (FKBP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FK506 Binding Protein 6 (FKBP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FK506 Binding Protein 6 (FKBP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 6 (FKBP6) ELISA Kit Customized Service Offer
  1. "A novel human gene FKBP6 is deleted in Williams syndrome."Genomics 52:130-137(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Autosomal dominant inheritance of Williams-Beuren syndrome in a father and son with haploinsufficiency for FKBP6."Clin. Dysmorphol. 14:61-65(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Mutations in the chromosome pairing gene FKBP6 are not a common cause of non-obstructive azoospermia."Mol. Hum. Reprod. 11:673-675(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Mutation screening of the FKBP6 gene and its association study with spermatogenic impairment in idiopathic infertile men."Reproduction 133:511-516(2007) [PubMed] [Europe PMC] [Abstract]
  8. "FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes."Biochemistry 47:6946-6952(2008) [PubMed] [Europe PMC] [Abstract]
  9. "FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor."J. Biol. Chem. 284:766-773(2009) [PubMed] [Europe PMC] [Abstract]