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Cell Division Cycle Protein 20 (CDC20)

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CDC20A; bA276H19.3; p55CDC

Cell Division Cycle Protein 20 (CDC20)
CCC E659
HGNC 1723
MGI 1859866
PubMed 19167333
RGD 620477
UniProt Q12834
Wiki CDC20
The cell-division cycle protein 20 is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APCCdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE659Hu01 Recombinant Cell Division Cycle Protein 20 (CDC20) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 20 (CDC20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 20 (CDC20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 20 (CDC20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 20 (CDC20) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 20 (CDC20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 20 (CDC20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 20 (CDC20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 20 (CDC20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 20 (CDC20) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Cell Division Cycle Protein 20 (CDC20) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Cell Division Cycle Protein 20 (CDC20) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Cell Division Cycle Protein 20 (CDC20) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Cell Division Cycle Protein 20 (CDC20) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cell Division Cycle Protein 20 (CDC20) ELISA Kit Customized Service Offer
  1. "A novel mammalian protein, p55CDC, present in dividing cells is associated with protein kinase activity and has homology to the Saccharomyces cerevisiae cell division cycle proteins Cdc20 and Cdc4."Mol. Cell. Biol. 14:3350-3363(1994) [PubMed] [Europe PMC] [Abstract]
  2. "Activation of the human anaphase-promoting complex by proteins of the CDC20/Fizzy family."Curr. Biol. 8:1207-1210(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1."Mol. Cell 2:163-171(1998) [PubMed] [Europe PMC] [Abstract]
  7. "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation."Genes Dev. 12:1871-1883(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Regulation of APC activity by phosphorylation and regulatory factors."J. Cell Biol. 146:791-800(1999) [PubMed] [Europe PMC] [Abstract]
  9. "MAD2B is an inhibitor of the anaphase-promoting complex."Genes Dev. 15:1765-1770(2001) [PubMed] [Europe PMC] [Abstract]
  10. "Mitotic regulation of the human anaphase-promoting complex by phosphorylation."EMBO J. 22:6598-6609(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint."Mol. Cell 16:387-397(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex."J. Biol. Chem. 282:17712-17719(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities."Nature 446:876-881(2007) [PubMed] [Europe PMC] [Abstract]
  14. "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction."Nat. Cell Biol. 10:1411-1420(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "APC/C- and Mad2-mediated degradation of Cdc20 during spindle checkpoint activation."Cell Cycle 8:167-171(2009) [PubMed] [Europe PMC] [Abstract]
  17. "CDK5RAP2 is required for spindle checkpoint function."Cell Cycle 8:1206-1216(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer."Exp. Mol. Pathol. 88:225-233(2010) [PubMed] [Europe PMC] [Abstract]
  19. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  20. "APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment."Nat. Cell Biol. 13:1234-1243(2011) [PubMed] [Europe PMC] [Abstract]
  21. "SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity."Cancer Cell 20:487-499(2011) [PubMed] [Europe PMC] [Abstract]
  22. "Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit."Nat. Commun. 3:894-894(2012) [PubMed] [Europe PMC] [Abstract]