≡

FK506 Binding Protein 8 (FKBP8)

[Edit]

FKBP38; FKBPr38; Rotamase; 38 kDa FK506-binding protein; Peptidyl-prolyl cis-trans isomerase FKBP8

FK506 Binding Protein 8 (FKBP8)
CCC E678
HGNC 3724
MGI 1341070
PubMed 18590716
RGD 1308670
UniProt Q14318
Wiki FKBP8
FK506-binding protein 8 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.The deduced 355-amino acid protein shares 26 to 28% sequence identity with other known human FKBPs. FKBP8 contains an N-terminal domain that is 33% identical to that of FKBP12 (FKBP1A), a putative leucine zipper domain, a 3-unit imperfect tetratricopeptide repeat (TPR) domain, and a putative calmodulin-binding domain. Northern blot analysis detected a single, approximately 1.35- to 2.4-kb FKBP8 transcript in all human tissues examined, with the highest expression in brain.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE678Hu01 Recombinant FK506 Binding Protein 8 (FKBP8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE678Hu01 Polyclonal Antibody to FK506 Binding Protein 8 (FKBP8) WB; IHC; ICC; IP.
LAE678Hu71 Biotin-Linked Polyclonal Antibody to FK506 Binding Protein 8 (FKBP8) WB; IHC; ICC.
MAE678Hu21 Monoclonal Antibody to FK506 Binding Protein 8 (FKBP8) WB; IHC; ICC; IP.
MAE678Hu22 Monoclonal Antibody to FK506 Binding Protein 8 (FKBP8) WB; IHC; ICC; IP.
Assay Kits SEE678Hu ELISA Kit for FK506 Binding Protein 8 (FKBP8) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE678Mu01 Recombinant FK506 Binding Protein 8 (FKBP8) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE678Mu01 Polyclonal Antibody to FK506 Binding Protein 8 (FKBP8) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for FK506 Binding Protein 8 (FKBP8) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 8 (FKBP8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant FK506 Binding Protein 8 (FKBP8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to FK506 Binding Protein 8 (FKBP8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to FK506 Binding Protein 8 (FKBP8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for FK506 Binding Protein 8 (FKBP8) CLIA Kit Customized Service Offer
n/a ELISA Kit for FK506 Binding Protein 8 (FKBP8) ELISA Kit Customized Service Offer
  1. "Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis."Nat. Cell Biol. 5:28-37(2003) [PubMed] [Europe PMC] [Abstract]
  2. "FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues."Development 131:2149-2159(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Characterization of a Bcl-XL-interacting protein FKBP8 and its splice variant in human RPE cells."Invest. Ophthalmol. Vis. Sci. 49:1721-1727(2008) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs."Gene 160:297-302(1995) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2."Biochem. Biophys. Res. Commun. 337:30-38(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin."EMBO J. 24:2688-2699(2005) [PubMed] [Europe PMC] [Abstract]
  10. "A reassessment of the inhibitory capacity of human FKBP38 on calcineurin."FEBS Lett. 579:1591-1596(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)."FEBS Lett. 579:1469-1476(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression."J. Biol. Chem. 281:40493-40502(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Hepatitis C virus non-structural protein NS5A interacts with FKBP38 and inhibits apoptosis in Huh7 hepatoma cells."FEBS Lett. 580:4392-4400(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse."Genes Cells 13:635-651(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria."Nat. Cell Biol. 17:160-169(2015) [PubMed] [Europe PMC] [Abstract]
  18. "Solution structure of the FK506-binding domain of human FKBP38."J. Biomol. NMR 34:197-202(2006) [PubMed] [Europe PMC] [Abstract]
  19. "Solution structure of RSGI RUH-047, an FKBP domain from human cDNA."Submitted (JUN-2006) to the PDB data bank
  20. "Structure of the human FK-506 binding protein 8."Submitted (OCT-2006) to the PDB data bank
  21. "A charge-sensitive loop in the FKBP38 catalytic domain modulates Bcl-2 binding."J. Mol. Recognit. 24:23-34(2011) [PubMed] [Europe PMC] [Abstract]