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Glomulin (GLMN)

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FAP; FAP48; FAP68; FKBPAP; GLML; GVM; VMGLOM; FK506-binding protein-associated protein; FKBP Associated Protein; Venous Malformation With Glomus Cells

Glomulin (GLMN)
CCC E682
HGNC 14373
MGI 2141180
PubMed 22405651
RGD 1588600
UniProt Q92990
Wiki GLMN
Glomulin is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.
The cDNA sequence encodes a protein of 417 amino acids. This novel protein, named FAP48 for FKBP-associated protein, can interact with FKBP59 and FKBP12 both in vitro and in vivo; however, binding is inhibited by FK506 and rapamycin in a dose-dependent manner. FAP48 may therefore represent a naturally occurring ligand of these immunosuppressant drug receptors.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glomulin (GLMN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glomulin (GLMN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glomulin (GLMN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glomulin (GLMN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glomulin (GLMN) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE682Mu01 Recombinant Glomulin (GLMN) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE682Mu01 Polyclonal Antibody to Glomulin (GLMN) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Glomulin (GLMN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glomulin (GLMN) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Glomulin (GLMN) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Glomulin (GLMN) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Glomulin (GLMN) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Glomulin (GLMN) CLIA Kit Customized Service Offer
n/a ELISA Kit for Glomulin (GLMN) ELISA Kit Customized Service Offer
  1. "FAP48, a new protein that forms specific complexes with both immunophilins FKBP59 and FKBP12. Prevention by the immunosuppressant drugs FK506 and rapamycin."J. Biol. Chem. 271:32923-32929(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Ligand-regulated binding of FAP68 to the hepatocyte growth factor receptor."J. Biol. Chem. 276:46632-46638(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Mutations in a novel factor, glomulin, are responsible for glomuvenous malformations ('glomangiomas')."Am. J. Hum. Genet. 70:866-874(2002) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The FKBP-associated protein FAP48 is an antiproliferative molecule and a player in T cell activation that increases IL2 synthesis."Proc. Natl. Acad. Sci. U.S.A. 100:2444-2449(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Mutation of FKBP associated protein 48 (FAP48) at proline 219 disrupts the interaction with FKBP12 and FKBP52."Regul. Pept. 97:147-152(2001) [PubMed] [Europe PMC] [Abstract]
  8. "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis."Proc. Natl. Acad. Sci. U.S.A. 100:9855-9860(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  12. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]