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Sphingosine-1-Phosphate Phosphatase 1 (SGPP1)

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SPPase1

Sphingosine-1-Phosphate Phosphatase 1 (SGPP1)
CCC E696
HGNC 17720
MGI 2135760
PubMed 24145350
RGD 727829
UniProt Q9BX95
Wiki SGPP1
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides .
The deduced 430-amino acid mouse protein shares 17% amino acid identity with yeast Lbp1. The deduced 441-amino acid protein shares 76% amino acid identity with its mouse homolog. Transfection of HEK293 or Chinese hamster ovary (CHO) cells with SGPP1 resulted in marked increase in SGPP1 activity in membrane fractions. SGPP1 was highly specific toward long-chain sphingoid base phosphates and degraded S1P, dihydro-S1P, and phyto-S1P. SGPP1 activity was independent of any cation requirements, including Mg(2+), and was not inhibited by EDTA but was inhibited by Zn(2+).

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE696Hu01 Recombinant Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE696Hu21 Monoclonal Antibody to Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) WB; IHC; ICC; IP.
PAE696Hu01 Polyclonal Antibody to Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) WB; IHC; ICC; IP.
Assay Kits SEE696Hu ELISA Kit for Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE696Ra01 Recombinant Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAE696Ra21 Monoclonal Antibody to Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) WB; IHC; ICC; IP.
PAE696Ra01 Polyclonal Antibody to Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) WB; IHC; ICC; IP.
Assay Kits SEE696Ra ELISA Kit for Sphingosine-1-Phosphate Phosphatase 1 (SGPP1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability."J. Biol. Chem. 278:34541-34547(2003) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]