≡

Sphingosine Kinase 2 (SPHK2)

[Edit]

Sphingosine Kinase 2 (SPHK2)
CCC E699
HGNC 18859
MGI 1861380
PubMed 16118219
RGD 1307757
UniProt Q9NRA0
Wiki SPHK2
SPHK2 contains the 5 highly conserved regions identified in SPHK1, although the GGKGK positively charged motif of SPHK1 is modified to GGRGL in SPHK2. In addition, SPHK2 has a region homologous to the diacylglycerol kinase catalytic site. SPHK2 shares 83% identity with mouse Sphk2. Northern blot analysis revealed a 2.8-kb transcript expressed in all 12 tissues tested, with highest expression in kidney, liver, and brain. Northern blot analysis of a mouse tissue panel revealed ubiquitous expression of a 3.1-kb transcript, with highest expression in liver and heart.SPHK2 associated with HDAC1 and HDAC2 in repressor complexes and was selectively enriched at the promoters of the genes encoding the cyclin-dependent kinase inhibitor p21 or the transcriptional regulator c-fos, where it enhanced local histone H3 acetylation and transcription.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE699Hu01 Recombinant Sphingosine Kinase 2 (SPHK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE699Hu01 Polyclonal Antibody to Sphingosine Kinase 2 (SPHK2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Sphingosine Kinase 2 (SPHK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sphingosine Kinase 2 (SPHK2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE699Mu01 Recombinant Sphingosine Kinase 2 (SPHK2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE699Mu01 Polyclonal Antibody to Sphingosine Kinase 2 (SPHK2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Sphingosine Kinase 2 (SPHK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sphingosine Kinase 2 (SPHK2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sphingosine Kinase 2 (SPHK2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sphingosine Kinase 2 (SPHK2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sphingosine Kinase 2 (SPHK2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sphingosine Kinase 2 (SPHK2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sphingosine Kinase 2 (SPHK2) ELISA Kit Customized Service Offer
  1. "Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform."J. Biol. Chem. 275:19513-19520(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Integral and associated lysosomal membrane proteins."Traffic 8:1676-1686(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A lipid binding domain in sphingosine kinase 2."Biochem. Biophys. Res. Commun. 380:87-92(2009) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]