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Tubulin Beta 1 (TUBb1)

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Tubulin Beta 1 (TUBb1)
CCC E707
HGNC 16257
MGI 107814
PubMed 15956286
UniProt Q9H4B7
Wiki TUBB1
Microtubules are involved in a wide variety of cellular processes, including mitosis, morphogenesis, platelet formation, and mobility of cilia and flagella. Circulating platelets carry a single marginal microtubule coil that is wound in 8 to 12 turns and is responsible for platelet shape. TUBB1 is the major beta-tubulin expressed in platelets and megakaryocytes and is required for optimal platelet assembly
Northern blot analysis of several adult mouse tissues detected highest Tubb1 expression in spleen, with much lower expression in lung. Weak expression was detected in spleen, liver, and lung of young mice.the C terminus of mouse Tubb1 interacted with the protease inhibitor Slpi.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE707Hu01 Recombinant Tubulin Beta 1 (TUBb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE707Hu01 Polyclonal Antibody to Tubulin Beta 1 (TUBb1) WB; IHC; ICC/IF
Assay Kits SEE707Hu ELISA Kit for Tubulin Beta 1 (TUBb1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE707Mu01 Recombinant Tubulin Beta 1 (TUBb1) Positive Control; Immunogen; SDS-PAGE; WB.
RPE707Mu02 Recombinant Tubulin Beta 1 (TUBb1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE707Mu01 Polyclonal Antibody to Tubulin Beta 1 (TUBb1) WB; IHC; ICC; IP.
PAE707Mu02 Polyclonal Antibody to Tubulin Beta 1 (TUBb1) WB; IHC; ICC; IP.
MAE707Mu21 Monoclonal Antibody to Tubulin Beta 1 (TUBb1) WB; IHC; ICC; IP.
Assay Kits SEE707Mu ELISA Kit for Tubulin Beta 1 (TUBb1) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  4. "RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules."J. Biol. Chem. 283:14109-14119(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation."Cell 137:1076-1087(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Tumoral and tissue-specific expression of the major human beta-tubulin isotypes."Cytoskeleton 67:214-223(2010) [PubMed] [Europe PMC] [Abstract]
  7. "The TUBB1 Q43P functional polymorphism reduces the risk of cardiovascular disease in men by modulating platelet function and structure."Blood 106:2356-2362(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly."Blood 113:458-461(2009) [PubMed] [Europe PMC] [Abstract]