Tubulin Beta 2B (TUBb2B)

TUBB2B has only a single synonymous substitution compared with TUBB2A, and it is highly similar to TUBB2C. In situ hybridization to mouse embryos showed that Tubb2b expression was restricted to the central and peripheral nervous system. Expression predominated in the cortical plate and within a thin layer of subplate, suggesting expression during neuronal migration and differentiation. Strong labeling in the developing cortex decreased after birth, but remained intense in the adult cerebellum, hippocampus, and olfactory bulb.wildtype human TUBB2B could form functional alpha/beta tubulin heterodimers. Knockdown of Tubb2b in the developing rat brain via small hairpin RNAs showed that Tubb2b was required for proper neuronal migration.