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Xeroderma Pigmentosum, Complementation Group F (XPF)

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ERCC4; RAD1; Excision Repair Cross-Complementing Rodent Repair Deficiency,Complementation 4; DNA repair protein complementing XP-F cells; DNA excision repair ERCC-4

Xeroderma Pigmentosum, Complementation Group F (XPF)
CCC E731
HGNC 3436
MGI 1354163
PubMed 23623386
RGD 1560340
UniProt Q92889
Wiki ERCC4
The predicted human ERCC4 protein has 2 leucine zipper domains in the N-terminal region. ERCC4 protein expressed in mammalian cells has a molecular mass of 110-kD by Western blot analysis. In cells of an XPF patient, ERCC4 protein levels were less than 5% of normal. Nucleotide excision repair (NER), which is defective in xeroderma pigmentosum, involves incision of a DNA strand on each side of a lesion.
There is evidence that the 2 incisions made during NER are catalyzed by separate DNA endonucleases. In humans, XPG endonuclease makes the 3-prime incision relative to the lesion. The ERCC4 gene encodes a protein that together with ERCC1 make up the ERCC1-XPF 5-prime endonuclease.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE731Hu01 Recombinant Xeroderma Pigmentosum, Complementation Group F (XPF) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE731Hu01 Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group F (XPF) WB; IHC; ICC; IP.
MAE731Hu21 Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group F (XPF) WB; IHC; ICC; IP.
Assay Kits SEE731Hu ELISA Kit for Xeroderma Pigmentosum, Complementation Group F (XPF) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Xeroderma Pigmentosum, Complementation Group F (XPF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group F (XPF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group F (XPF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Xeroderma Pigmentosum, Complementation Group F (XPF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Xeroderma Pigmentosum, Complementation Group F (XPF) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Xeroderma Pigmentosum, Complementation Group F (XPF) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Xeroderma Pigmentosum, Complementation Group F (XPF) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Xeroderma Pigmentosum, Complementation Group F (XPF) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Xeroderma Pigmentosum, Complementation Group F (XPF) CLIA Kit Customized Service Offer
n/a ELISA Kit for Xeroderma Pigmentosum, Complementation Group F (XPF) ELISA Kit Customized Service Offer
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  21. "Mutations in ERCC4, encoding the DNA-repair endonuclease XPF, cause Fanconi anemia." Am. J. Hum. Genet. 92:800-806(2013) [PubMed] [Europe PMC] [Abstract]
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