≡

Phosphoglucomutase 3 (PGM3)

[Edit]

AGM1; PAGM; Phosphoacetylglucosamine Mutase; Acetylglucosamine Phosphomutase; N-acetylglucosamine-phosphate mutase

Phosphoglucomutase 3 (PGM3)
CCC E743
HGNC 8907
MGI 97566
PubMed 24698316
RGD 1305221
UniProt O95394
Wiki PGM3
The interaction of erythropoietin (EPO) with the EPO receptor (EPOR) activates multiple signaling cascades. The deduced 542-amino acid AGM1 protein is identical to human N-acetylglucosamine-phosphate mutase . It contains a 10-amino acid segment showing high similarity with the putative active site motif of several hexose phosphate mutases.
Northern blot analysis detected a major, approximately 2.4-kb AGM1 transcript in all human tissues tested except lung, with relatively high expression in pancreas, heart, liver, and placenta, and relatively low expression in brain, skeletal muscle, and kidney. Two minor transcripts of approximately 5 and 8 kb were also found in all tissues except lung.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE743Hu01 Recombinant Phosphoglucomutase 3 (PGM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAE743Hu01 Polyclonal Antibody to Phosphoglucomutase 3 (PGM3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phosphoglucomutase 3 (PGM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoglucomutase 3 (PGM3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPE743Mu01 Recombinant Phosphoglucomutase 3 (PGM3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Phosphoglucomutase 3 (PGM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoglucomutase 3 (PGM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoglucomutase 3 (PGM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoglucomutase 3 (PGM3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphoglucomutase 3 (PGM3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphoglucomutase 3 (PGM3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphoglucomutase 3 (PGM3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphoglucomutase 3 (PGM3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphoglucomutase 3 (PGM3) ELISA Kit Customized Service Offer
  1. "Cloning and characterization of complementary DNA encoding human N-acetylglucosamine-phosphate mutase protein."Gene 242:97-103(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis."Biochim. Biophys. Acta 1492:369-376(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  7. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  13. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  14. "PGM3 mutations cause a congenital disorder of glycosylation with severe immunodeficiency and skeletal dysplasia." Am. J. Hum. Genet. 95:96-107(2014) [PubMed] [Europe PMC] [Abstract]
  15. "Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment." J. Allergy Clin. Immunol. 133:1400-1409(2014) [PubMed] [Europe PMC] [Abstract]
  16. "Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels." J. Allergy Clin. Immunol. 133:1410-1419(2014) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Identification of human phosphoglucomutase 3 (PGM3) as N-acetylglucosamine-phosphate mutase (AGM1)."Ann. Hum. Genet. 66:139-144(2002) [PubMed] [Europe PMC] [Abstract]